...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Comparison of three different mediastinal radiotherapy techniques in female patients: Impact on heart sparing and dose to the breasts.
【24h】

Comparison of three different mediastinal radiotherapy techniques in female patients: Impact on heart sparing and dose to the breasts.

机译：女性患者三种不同的纵隔放疗技术的比较：对心脏节约和乳房剂量的影响。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND AND PURPOSE: To study different radiotherapy techniques for female patients with mediastinal target volumes. Especially in highly curable diseases such as lymphoma, long-term survivors might develop late cardiac damage and radiation-induced second cancer. PATIENTS AND METHODS: Planning CT scans were obtained in eight cases. We contoured the clinical target volume (three different scenarios with or without lower mediastinum and hili) and organs at risk and compared standard 6MV ap-pa opposed fields to a 3D conformal 4-field technique and a 7-field step-and-shoot IMRT technique and evaluated DVHs for each structure. The planning system was BrainSCAN 5.21 (BrainLAB, Heimstetten, Germany). RESULTS: Target volume coverage did not improve significantly with 4-field or IMRT techniques. However, IMRT resulted in better dose reduction to the heart than the other techniques. The median heart dose (intermediately sized target volume) was 98% (95-100) with ap-pa fields, 56% (52-79) with the 4-field technique, and 39% (36-65) with IMRT, for example (p<0.05). Better heart sparing was achieved at all dose levels down to the 15% isodose. The median maximum dose to the breasts was lowest with IMRT. The breast volume receiving low doses (15% or less), however, was highest with IMRT. There was also a disadvantage in mean lung dose. CONCLUSIONS: IMRT might result in a reduced cardiac complication risk. In younger females, however, this advantage might be offset by the risk of breast cancer. The best technique for a given patient depends on age, comorbidity, and the individual risk estimates for breast cancer and cardiac morbidity, respectively.
机译：背景与目的：研究针对纵隔目标量的女性患者的不同放疗技术。特别是在高度可治愈的疾病（例如淋巴瘤）中，长期幸存者可能会发展为晚期心脏损害和辐射诱发的第二种癌症。患者和方法：8例患者获得了计划的CT扫描。我们勾画出了临床目标体积（有或没有较低纵隔和幽门的三种不同情况）和有风险的器官的轮廓，并将标准的6MV ap-pa相对野与3D保形4野技术和7野逐步IMRT进行了比较技术并评估了每种结构的DVH。计划系统是BrainSCAN 5.21（德国Heimstetten的BrainLAB）。结果：4场或IMRT技术的目标体积覆盖率没有显着提高。但是，IMRT可以比其他技术更好地减少心脏的剂量。对于ap-pa场，中位心脏剂量（中等大小的目标体积）为98％（95-100），采用4场技术时为56％（52-79），而使用IMRT时为39％（36-65）。例子（p <0.05）。在低至15％等剂量的所有剂量水平下，均能更好地保留心脏。 IMRT对乳房的最大中位剂量最低。接受低剂量（15％或更少）的乳房体积是IMRT的最高值。平均肺部剂量也有缺点。结论：IMRT可能会降低心脏并发症的风险。但是，在年轻女性中，这种优势可能会被患乳腺癌的风险所抵消。给定患者的最佳技术分别取决于年龄，合并症以及乳腺癌和心脏病的个体风险估计。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号