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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >High dose rate prostate brachytherapy: the California Endocurietherapy (CET) method.
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High dose rate prostate brachytherapy: the California Endocurietherapy (CET) method.

机译：高剂量率前列腺近距离放射疗法：加利福尼亚内分泌疗法（CET）方法。

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摘要

BACKGROUND AND PURPOSE: To describe the rationale, protocol and procedure for the treatment of prostate cancer using high dose rate brachytherapy (HDR-BT) and a non-fixed template technique. MATERIALS AND METHODS: Between July 1991 and December 1998, 491 patients with carcinoma of the prostate were treated using HDR-BT and a non-fixed template technique. AJC stages T(1C)-T(3B), patients with prior transurethral resections of the prostate (TURP) and gland volumes >60 cm(3), were included. Flexible cystoscopy, fluoroscopy and transrectal ultrasound (TRUS) were used and 17 flexiguides were inserted through the perineum. Dosimetry was carried out using localization films. Treatment volume was defined at 4-6 mm outside the peripheral catheters. BT consisted of two implants, separated by 1 week, with two fractions given per implant for a total of four HDR fractions. Dose prescription to the treatment volume was 6 Gy (HDR) per fraction, with an additional dose of 0.5 to 0.75 Gy given where required. RESULTS: Patients with glands >60 cm(3), narrow pubic arches and TURP defects were treated satisfactorily. Symptoms of urinary irritation occurred with variable intensity and abated rapidly 2 weeks after the procedures. There was no high-grade chronic rectal morbidity and most patients reported no rectal symptoms or treatment-related chronic urinary incontinence. CONCLUSIONS: The non-fixed template technique allowed flexibility in flexiguide placement to encompass large glands (>60 cm(3)), extracapsular extension and seminal vesicle involvement without the need for additional flexiguides. Also, small pubic arches and TURP defects posed little problem in positioning the flexiguides. This versatility resulted in complete treatment volume coverage of the prostate.
机译：背景与目的：描述使用高剂量率近距离放射治疗（HDR-BT）和非固定模板技术治疗前列腺癌的原理，方案和程序。材料与方法：在1991年7月至1998年12月之间，使用HDR-BT和非固定模板技术治疗了491例前列腺癌患者。包括AJC阶段T（1C）-T（3B），先前经尿道前列腺切除术（TURP）和腺体体积> 60 cm（3）的患者。使用了柔性膀胱镜检查，透视检查和经直肠超声检查（TRUS），并在会阴部插入了17根挠性导引器。使用定位膜​​进行剂量测定。治疗体积限定在外周导管外4-6mm。 BT由两个植入物组成，相隔1周，每个植入物给出两个分数，总共四个HDR分数。治疗剂量的剂量处方为每级分6 Gy（HDR），并在需要时给予0.5至0.75 Gy的额外剂量。结果：腺体> 60 cm（3），耻骨弓狭窄和TURP缺损的患者得到了令人满意的治疗。尿刺激的症状发生在不同的强度，并在手术后2周迅速减轻。没有高度的慢性直肠疾病，大多数患者没有直肠症状或与治疗有关的慢性尿失禁。结论：非固定模板技术允许灵活的指南中放置的灵活性，以涵盖大腺体（> 60 cm（3）），囊外延伸和精囊囊肿的参与，而无需额外的flexguides。同样，小的耻骨弓和TURP缺损在放置弹性导板时几乎没有问题。这种多功能性导致前列腺的治疗体积完全覆盖。

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