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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Feasibility of using intravenous contrast-enhanced computed tomography (CT) scans in lung cancer treatment planning.
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Feasibility of using intravenous contrast-enhanced computed tomography (CT) scans in lung cancer treatment planning.

机译：在肺癌治疗计划中使用静脉对比增强计算机断层扫描（CT）扫描的可行性。

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BACKGROUND AND PURPOSE: To investigate the feasibility of using intravenous contrast-enhanced computed tomography (CT) scans in 3-dimensional conformal radiotherapy (3D-CRT), stereotactic body radiation therapy (SBRT) and intensity-modulated radiotherapy (IMRT) treatment planning for lung cancers, respectively. MATERIALS AND METHODS: Twelve patients with bulky lung tumors and 14 patients with small lung tumors were retrospectively analyzed. Each patient took two sets of CT in the same position with active breathing control (ABC) technique before and after intravenous contrast agent (CA) injections. Bulky tumors were planned with 3D-CRT, while SBRT plans were generated for patients with small tumors based on CT scans with intravenous CA. In addition, IMRT plans were generated for patients with bulky tumors to continue on a planning study. All plans were copied and replaced on the scans without intravenous CA. The radiation doses calculated from the two sets of CTs were compared with regard to planning volumes (PTV), the organ at-risk (OAR) and the lungs using Wilcoxon's signed rank test. RESULTS: In comparisons for 3D-CRT plans, CT scans with intravenous CA reduced the mean dose and the maximum dose of PTV with significant differences (p<0.05) that were within 1.0%. Comparing IMRT and SBRT plans, CT scans with intravenous CA obviously increased the minimum irradiation dose and dose of 95% volume of target received (D(95)) for targets, respectively (p<0.05). There was no statistical significance for lung parameters between two sets of scans in SBRT plans and IMRT plans. CONCLUSIONS: The enhanced CT scans can be used for both target delineation and treatment planning in 3D-CRT. The dose difference caused by intravenous CA is small. But for SBRT and IMRT, the minimum irradiation dose in targets may be estimated to be increased up to 2.71% while the maximum dose may be estimated to be decreased up to 1.36%. However, the difference in dose distribution in most cases were found to be clinical tolerable.
机译：背景与目的：探讨在3D保形放射治疗（3D-CRT），立体定向放射治疗（SBRT）和强度调制放射治疗（IMRT）治疗计划中使用静脉造影剂CT扫描的可行性分别是肺癌。材料与方法：回顾性分析12例大块肺肿瘤患者和14例小块肺肿瘤患者。每位患者在注射静脉造影剂（CA）之前和之后均采用主动呼吸控制（ABC）技术在同一位置进行两组CT检查。使用3D-CRT对大块肿瘤进行了计划，而基于静脉CA的CT扫描则为患有小肿瘤的患者生成了SBRT计划。此外，还为肿瘤较大的患者制定了IMRT计划，以继续进行计划研究。复制所有计划，并在无静脉CA的情况下进行扫描替换。使用Wilcoxon的符号秩和检验，比较了两组CT计算出的辐射剂量与计划体积（PTV），高危器官（OAR）和肺部。结果：与3D-CRT计划相比，静脉CA的CT扫描降低了PTV的平均剂量和最大剂量，差异显着（p <0.05）在1.0％以内。比较IMRT和SBRT计划，用静脉CA进行CT扫描明显增加了靶标的最低照射剂量和95％的靶标剂量（D（95））（p <0.05）。在SBRT计划和IMRT计划的两组扫描之间，肺参数没有统计学意义。结论：增强的CT扫描可用于3D-CRT的靶标勾画和治疗计划。静脉CA引起的剂量差异很小。但是对于SBRT和IMRT，目标的最小照射剂量可以估计增加到2.71％，而最大剂量可以减少到1.36％。但是，发现大多数情况下剂量分布的差异在临床上是可以忍受的。

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