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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma.
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Adjuvant inhibition of the epidermal growth factor receptor after fractionated irradiation of FaDu human squamous cell carcinoma.

机译：FaDu人鳞状细胞癌分次照射后对表皮生长因子受体的佐剂抑制。

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BACKGROUND AND PURPOSE: Experiments performed by others have shown that inhibition of EGFR before and after single dose irradiation prolonged growth delay and improved local tumour control. This suggests that adjuvant EGFR inhibition can inactivate clonogens that survived irradiation. To test this hypothesis local tumour control was investigated after fractionated radiotherapy and adjuvant EGFR-TK inhibition. MATERIALS AND METHODS: FaDu hSCC xenografts were irradiated with 30 fractions in 6 weeks with total doses of 30-100Gy. After the end of fractionated irradiation, BIBX1382BS was administered daily orally over a time period of 75 days. Tumour volumes were determined two times per week, the volume doubling time during adjuvant treatment was calculated for progressing and recurrent tumours. Local tumour control was investigated 120 days after end of irradiation. RESULTS: Adjuvant BIBX1382BS significantly reduced the tumour growth rate but did not improve local tumour control. The TCD(50) values were 66.1Gy (95% C.I.: 59; 73Gy) after adjuvant BIBX1382BS treatment and 67.9Gy (61; 75Gy) for control tumours (P=0.9). CONCLUSIONS: These data indicate that, although growth of recurrent tumour cells after irradiation is dependent on the EGFR pathway, tumour cells retain their clonogenic potential despite of EGFR inhibition. The results imply also that a decreased tumour growth rate does not necessarily allow conclusions on enhanced inactivation of clonogenic cells when antiproliferative drugs are combined with radiation.
机译：背景与目的：其他人进行的实验表明，单剂量照射前后对EGFR的抑制作用可延长生长延迟并改善局部肿瘤控制。这表明佐剂EGFR的抑制作用可以使存活下来的克隆原失活。为了检验该假设，在分级放疗和辅助EGFR-TK抑制后研究了局部肿瘤控制。材料与方法：FaDu hSCC异种移植物在6周内用30份辐照，总剂量为30-100Gy。分次照射结束后，在75天的时间内每天口服BIBX1382BS。每周两次确定肿瘤体积，计算辅助治疗期间肿瘤进展和复发的体积加倍时间。照射结束后120天，研究局部肿瘤的控制。结果：佐剂BIBX1382BS显着降低了肿瘤的生长速度，但没有改善局部肿瘤的控制。辅助性BIBX1382BS治疗后的TCD（50）值为66.1Gy（95％C.I .: 59; 73Gy），对照肿瘤的TCD（50）值为67.9Gy（61; 75Gy）（P = 0.9）。结论：这些数据表明，尽管辐射后复发性肿瘤细胞的生长取决于EGFR途径，但尽管EGFR被抑制，肿瘤细胞仍保留了其克隆能力。该结果还暗示，当抗增殖药与放射线结合使用时，降低的肿瘤生长率并不一定能得出有关克隆形成细胞失活增强的结论。

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