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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Tumor proliferation and apoptosis in human uterine cervix carcinoma I: correlations between variables.
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Tumor proliferation and apoptosis in human uterine cervix carcinoma I: correlations between variables.

机译：人宫颈癌的肿瘤增殖和凋亡I：变量之间的相关性。

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PURPOSE: Parameters for tumor proliferation and apoptosis were studied prospectively in 84 previously untreated patients with a diagnosis of carcinoma of the uterine cervix. MATERIALS AND METHODS: Tumor proliferation was assessed by in vivo labeling with bromodeoxyuridine (BrdU), followed by a biopsy of the tumor 4-10 h thereafter during an examination under anesthesia. The potential doubling time (Tpot) was obtained by deriving the BrdU labeling index (LI) and S-phase duration (Ts) using flow cytometry. The LI for BrdU and its staining pattern were also determined immunohistochemically. Apoptosis was assessed histologically using morphological criteria. RESULTS: Seven patients were excluded and the FIGO stages of the remaining 77 patients were as follows: IB and IIA, 20 patients; IIB, 29 patients; IIIB and IV, 28 patients. The median tumor diameter was 6 cm. There were 61 squamous cell, 11 adeno- and five adenosquamous carcinomas. Of the 63 patients in whom the tumor grade could be determined, 37 were well or moderately well differentiated and the remaining 26 were poorly differentiated. The median mitotic index (MI) was 0.7%. There were 43 diploid and 34 aneuploid tumors. Median values for Ts and S-phase fraction (SPF) were 9.9 h and 16%, respectively. The median BrdU LI by flow cytometry (LI-fc) was 6.7%. There was a significant correlation between LI-fc and LI by histology, although values for the latter (median 11.1%) were consistently higher than those determined by flow cytometry by a factor of 1.5. The median Tpot value was 5.0 days. The median apoptotic index (AI) was 1.0% and AI correlated positively with LI-fc. Median values for LI-fc increased with increasing tumor size and were 5.1%, 6.4%, 7.5% and 11.0% for tumors measuring < or = 4 cm, 4-6 cm, 6-8 cm and > 8 cm, respectively. The remaining proliferation parameters, however, showed no correlation with tumor size, stage, grade or histologic type. CONCLUSIONS: In carcinomas of the cervix, tumor proliferation is positively associated with apoptosis and tumor size. These findings suggest that parameters for tumor proliferation and apoptosis are associated with tumor progression and may thus be predictive of clinical outcome.
机译：目的：前瞻性研究了84例先前未经治疗的诊断为子宫颈癌的患者的肿瘤增殖和凋亡参数。材料与方法：通过在体内用溴脱氧尿苷（BrdU）标记，然后在麻醉下4-10 h进行活检，评估肿瘤的增殖。通过使用流式细胞仪推导BrdU标记指数（LI）和S期持续时间（Ts）获得潜在的倍增时间（Tpot）。还通过免疫组织化学测定了BrdU的LI及其染色模式。使用形态学标准对细胞凋亡进行组织学评估。结果：排除了7例患者，其余77例患者的FIGO分期如下：IB和IIA，20例; IIB，29例患者; IIIB和IV，28例。中位肿瘤直径为6cm。有61个鳞状细胞癌，11个腺癌和5个腺鳞癌。在可以确定肿瘤等级的63名患者中，有37例分化良好或中度良好，其余26例分化较差。中位数有丝分裂指数（MI）为0.7％。有43个二倍体和34个非整倍性肿瘤。 Ts和S相分数（SPF）的中位数分别为9.9 h和16％。流式细胞术（LI-fc）的BrdU LI中位数为6.7％。 LI-fc和LI的组织学之间存在显着相关性，尽管后者的值（中位数11.1％）始终比流式细胞术确定的高1.5倍。 Tpot的中值为5.0天。中位凋亡指数（AI）为1.0％，且AI与LI-fc正相关。 LI-fc的中位数值随肿瘤大小的增加而增加，对于尺寸≤4 cm，4-6 cm，6-8 cm和> 8 cm的肿瘤，LI-fc的中位数分别为5.1％，6.4％，7.5％和11.0％。然而，其余的增殖参数与肿瘤的大小，分期，等级或组织学类型无关。结论：在子宫颈癌中，肿瘤增殖与细胞凋亡和肿瘤大小成正相关。这些发现表明，肿瘤增殖和凋亡的参数与肿瘤进展有关，因此可以预测临床结果。

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