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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Monitoring of tumor reoxygenation following irradiation by 31P magnetic resonance spectroscopy: an experimental study of human melanoma xenografts.
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Monitoring of tumor reoxygenation following irradiation by 31P magnetic resonance spectroscopy: an experimental study of human melanoma xenografts.

机译：通过31P磁共振波谱监测辐射后的肿瘤复氧：人类黑素瘤异种移植物的实验研究。

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BACKGROUND AND PURPOSE: Inadequate tumor reoxygenation during radiation therapy may cause local treatment failure. This study was aimed at investigating the potential usefulness of 31P-MRS in monitoring tumor reoxygenation following radiation treatment. MATERIALS AND METHODS: Tumors of two human melanoma xenograft lines (BEX-t and HUX-t) were exposed to 15.0 Gy, and then the fraction of radiobiologically hypoxic cells, measured by using the paired survival curve method, or tumor bioenergetic status, measured by 31P-MRS as the (PCr + NTPbeta)/Pi resonance ratio, was determined versus time after the radiation exposure. RESULTS: Untreated BEX-t and HUX-t tumors showed similar fractions of radiobiologically hypoxic cells and similar bioenergetic status, whereas both parameters differed substantially between the lines in irradiated tumors. A close association was found between radiation-induced changes in tumor bioenergetic status and radiation-induced changes in the fraction of radiobiologically hypoxic cells. CONCLUSION: 31P-MRS is a potentially useful method for monitoring tumor reoxygenation following radiation treatment.
机译：背景与目的：放射治疗过程中肿瘤氧合不足可能会导致局部治疗失败。这项研究旨在调查31P-MRS在监测放射治疗后肿瘤再氧合方面的潜在用途。材料与方法：将两个人黑色素瘤异种移植物系（BEX-t和HUX-t）的肿瘤暴露于15.0 Gy，然后使用成对生存曲线法测量放射生物学缺氧细胞的比例，或测量肿瘤生物能状态通过31P-MRS作为（PCr + NTPbeta）/ Pi共振比，确定了辐射暴露后随时间的变化。结果：未经治疗的BEX-t和HUX-t肿瘤显示出相似的放射生物学缺氧细胞比例和相似的生物能状态，而在放射肿瘤中，这两个参数之间存在实质性差异。辐射引起的肿瘤生物能状态变化与放射诱导的缺氧细胞比例变化之间存在密切的联系。结论：31P-MRS是监测放射治疗后肿瘤复氧的潜在有用方法。

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