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首页> 外文期刊>Cell cycle >Exploring the activated adipogenic niche: Interactions of macrophages and adipocyte progenitors
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Exploring the activated adipogenic niche: Interactions of macrophages and adipocyte progenitors

机译：探索活化的脂肪生境：巨噬细胞和脂肪细胞祖细胞的相互作用

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摘要

Adult adipose tissue contains a large supply of progenitors that can renew fat cells for homeostatic tissue maintenance and adaptive growth or regeneration in response to external challenges. However, the in vivo mechanisms that control adipocyte progenitor behavior are poorly characterized. We recently demonstrated that recruitment of adipocyte progenitors by macrophages is a central feature of adipose tissue remodeling under various adipogenic conditions. Catabolic remodeling of white adipose tissue by β3-adrenergic receptor stimulation requires anti-inflammatory M2-polarized macrophages to clear dying adipocytes and to recruit new brown adipocytes from progenitors. In this Extra Views article, we discuss in greater detail the cellular elements of adipogenic niches and report a strategy to isolate and characterize the subpopulations of macrophages and adipocyte progenitors that actively participate in adrenergic tissue remodeling. Further characterization of these subpopulations may facilitate identification of new cellular targets to improve metabolic and immune function of adipose tissue.
机译：成人脂肪组织包含大量祖细胞，这些祖细胞可以更新脂肪细胞，以维持体内稳态组织并响应外部挑战而适应性生长或再生。但是，控制脂肪细胞祖细胞行为的体内机制尚不明确。我们最近证明巨噬细胞募集脂肪细胞祖细胞是在各种成脂条件下脂肪组织重塑的主要特征。通过β3-肾上腺素能受体刺激对白色脂肪组织进行分解代谢重塑需要消炎的M2极化巨噬细胞清除垂死的脂肪细胞并从祖细胞中募集新的棕色脂肪细胞。在这篇Extra Views文章中，我们将更详细地讨论脂肪形成壁ches的细胞成分，并报告一种策略，以分离和表征积极参与肾上腺能组织重塑的巨噬细胞和脂肪细胞祖细胞的亚群。这些亚群的进一步表征可能有助于鉴定新的细胞靶标，以改善脂肪组织的代谢和免疫功能。

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