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AhR: Far more than an environmental sensor

机译：AhR：远远不只是环境传感器

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摘要

The aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, acts as a heterodimeric transcriptional regulator. Widely expressed in a variety of animal species as well as in humans, AhR has constitutive functions that are only now beginning to be appreciated. The main focus is now shifting from the role of AhR in the hepatic clearance of xenobiotics toward the nature of its physiological ligands as well as its mode of action in response to functionally distinct molecules, disparate in nature as to their endogenous source and chemical structure. Animal and human data indicate that AhR is involved in various signaling pathways critical to cell normal homeosta-sis, which covers multiple aspects of physiology, such as cell proliferation and differentiation, gene regulation, cell motil-ity and migration, inflammation and others.
机译：芳基烃受体（AhR）是一种配体激活的转录因子，可作为异二聚体转录调节因子。 AhR在各种动物物种以及人类中广泛表达，其组成功能现在才开始被人们所认识。现在的主要焦点已从AhR在异源生物肝脏清除中的作用转移到其生理配体的性质及其对功能上不同的分子的反应模式，这些分子在性质上与内源和化学结构完全不同。动物和人类数据表明，AhR参与了各种对细胞正常体内平衡至关重要的信号传导途径，涵盖了生理学的多个方面，例如细胞增殖和分化，基因调控，细胞运动性和迁移，炎症等。

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