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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Evidence based radiation oncology: breast cancer.
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Evidence based radiation oncology: breast cancer.

机译：循证放射肿瘤学：乳腺癌。

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PURPOSE: Radiotherapy is, similar to surgery, a local treatment. In the case of breast cancer, it is generally given after conservative or after more extensive, tumour and patient adapted, surgery. The target volumes can be the breast and/or the thoracic wall and/or the regional lymph node areas. The integration and the extent of radiotherapy as part of the comprehensive treatment of the breast cancer patient, including the amount of surgery and the sequencing with the systemic treatments, has to be well discussed with all medical specialists involved in treating breast cancer on a multidisciplinary basis. Guidelines for the appropriate prescription and execution of radiotherapy are of utmost importance. However, individualisation based on the individual patients' and tumours' characteristics should always be envisaged. MATERIALS AND METHODS: Based on a review of the literature the level of evidence that is available for the indications for radiotherapy is summarised, as well as the main clinical questions that are unanswered today. An overview of the recent and ongoing clinical trails in breast cancer will highlight some of the current ongoing debates. CONCLUSIONS: In the case of breast cancer, radiotherapy, given after as well conservative as extensive risk-adapted surgery, significantly reduces the risk of local and regional recurrences. Especially for patients with an intermediate to high absolute risk for local recurrences, a positive influence on overall survival has been shown, notably when appropriate radiotherapy techniques are used. Most important is that the best results that we can offer to our breast cancer patients for all clinical endpoints (local and regional control; quality of life; cosmetic results; survival) can be obtained by a multidisciplinary and patient-oriented approach, involving all those involved in the treatment of breast cancer patients.
机译：目的：放疗类似于外科手术，是局部治疗。在乳腺癌的情况下，通常在保守治疗后或在更广泛的肿瘤和患者适应性手术后进行。目标体积可以是乳房和/或胸壁和/或区域淋巴结区域。乳腺癌综合治疗中放疗的整合和范围（包括手术量和全身治疗的顺序）必须与参与多学科治疗乳腺癌的所有医学专家进行充分讨论。适当处方和放疗的实施准则至关重要。但是，应始终根据个体患者和肿瘤的特点进行个体化。材料与方法：在对文献进行回顾的基础上，总结了可用于放射治疗指征的证据水平，以及当今尚未解决的主要临床问题。对近期和正在进行的乳腺癌临床研究的概述将突出一些当前正在进行的辩论。结论：在乳腺癌的情况下，放疗是在保守治疗以及广泛适应风险的手术后进行的，可显着降低局部和区域性复发的风险。特别是对于局部复发具有中度至高度绝对风险的患者，已显示出对整体生存的积极影响，尤其是当使用适当的放射治疗技术时。最重要的是，我们可以通过多学科和以患者为中心的方法，为我们的乳腺癌患者提供所有临床终点（局部和区域控制;生活质量;美容效果;生存率）的最佳结果。参与乳腺癌患者的治疗。

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