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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >A verification study of proposed pelvic lymph node localisation guidelines using nanoparticle-enhanced magnetic resonance imaging.
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A verification study of proposed pelvic lymph node localisation guidelines using nanoparticle-enhanced magnetic resonance imaging.

机译：对使用纳米颗粒增强磁共振成像的骨盆淋巴结定位指南的验证研究。

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BACKGROUND AND PURPOSE: Normal sized pelvic lymph nodes are not easily identifiable on conventional imaging, but can be visualised with contrast-enhanced magnetic resonance imaging (MRI) using intravenous ultra-small particles of iron-oxide (USPIO). We have previously reported pelvic node clinical target volume (CTV) delineation guidelines for use with conventional imaging, derived from nodal mapping studies using USPIO. This study aims to verify these guidelines using an independent observer in a further patient cohort. MATERIALS AND METHODS: Ten patients with gynaecological cancer underwent MRI with and without intravenous USPIO. The guidelines were used to outline a pelvic node CTV on pre-contrast T2-weighted images. On post-contrast T2-weighted images the pelvic nodes were identified and outlined. The pre- and post-contrast images were co-registered and CTV examined for node coverage. RESULTS: By applying the guidelines, full coverage of 737 of 741 node outlines was achieved (>99%). Four nodes werenot completely encompassed, two anterior external iliac nodes and two lateral external iliac nodes. CONCLUSIONS: MRI with USPIO contrast enabled the production of guidelines for localising a pelvic node CTV with conventional imaging. Application of these guidelines to a further patient cohort resulted in coverage of 99.5% node outlines demonstrating the reliability of this technique.
机译：背景与目的：正常大小的盆腔淋巴结在常规成像中不易识别，但可以使用静脉内超细氧化铁（USPIO）造影剂增强磁共振成像（MRI）进行可视化。我们先前已经报道了常规成像使用的盆腔淋巴结临床目标体积（CTV）划定指南，该指南源自使用USPIO进行的淋巴结定位研究。本研究旨在通过在更多患者队列中使用独立的观察员来验证这些指南。材料与方法：十名妇科癌症患者接受或不接受静脉USPIO接受MRI检查。该指南用于在对比前T2加权图像上勾勒出骨盆结节CTV。在对比后的T2加权图像上，可以识别并勾勒出骨盆结点。对比前和对比后的图像进行了配准，并检查了CTV的节点覆盖率。结果：通过应用指南，实现了741个节点轮廓中的737个的完全覆盖（> 99％）。四个结节没有完全被包围，两个two外结节和两个外侧lateral结节。结论：采用USPIO对比的MRI能够产生使用常规成像定位盆腔结节CTV的指南。将这些指南应用到更多的患者队列中，覆盖了99.5％的节点轮廓，证明了该技术的可靠性。

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