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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Post-prostatectomy radiation therapy: Consensus guidelines of the Australian and New Zealand Radiation Oncology Genito-Urinary Group.
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Post-prostatectomy radiation therapy: Consensus guidelines of the Australian and New Zealand Radiation Oncology Genito-Urinary Group.

机译：前列腺切除术后放射疗法：澳大利亚和新西兰放射肿瘤学生殖泌尿小组的共识指南。

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BACKGROUND AND PURPOSE: Three randomised trials have demonstrated the benefit of adjuvant post-prostatectomy radiotherapy (PPRT) for high risk patients. Data also documents the effectiveness of salvage radiotherapy following a biochemical relapse post-prostatectomy. The Radiation Oncology Genito-Urinary Group recognised the need to develop consensus guidelines on to whom, when and how to deliver PPRT. MATERIALS AND METHODS: Draft guidelines were developed and refined at a consensus conference in June 2006 attended by 63 delegates where urological, radiotherapy and diagnostic imaging experts spoke on aspects of PPRT. Unresolved issues were further developed by working parties and redistributed until consensus was reached. RESULTS: Central to the recommendations is that patients with positive surgical margins, seminal vesicle invasion and/or extracapsular extension have a high risk of residual local disease and should be informed of the options of either immediate adjuvant radiotherapy or active surveillance with early salvage in the event of biochemical recurrence. Salvage radiotherapy should be instituted at the earliest confirmation of biochemical recurrence. Detailed contouring guidelines have been developed, defining the regions at risk of residual microscopic disease which should be included in the clinical target volume. The recommended doses are 60-64Gy for adjuvant, and 60-66Gy for salvage radiotherapy. The role of hormone therapy in conjunction with PPRT is yet to be defined. CONCLUSIONS: These consensus guidelines have been developed to give clinical and technical guidance to radiation oncologists and urologists in the management of high risk post-prostatectomy patients.
机译：背景与目的：三项随机试验已证明前列腺切除术后辅助放疗对高危患者的益处。数据还记录了前列腺切除术后生化复发后抢救放疗的有效性。放射肿瘤学生殖泌尿学小组认识到有必要针对谁，何时以及如何向其提供PPRT制定共识性指南。材料与方法：指南草案是在2006年6月的一次共识会议上制定和完善的，共有63位代表参加，泌尿外科，放射治疗和诊断成像专家就PPRT的各个方面进行了演讲。未解决的问题由工作组进一步制定，并重新分配，直到达成共识为止。结果：建议的核心是手术切缘阳性，精囊侵犯和/或囊外扩张的患者存在残留局部疾病的高风险，应告知患者立即辅助放疗或在早期抢救时进行主动监护的选择生化复发事件。在生化复发确认后应尽早进行挽救性放疗。已经制定了详细的轮廓指南，定义了存在残留显微疾病风险的区域，这些区域应包括在临床目标体积中。对于佐剂，推荐剂量为60-64Gy，对于挽救性放疗，推荐剂量为60-66Gy。激素治疗与PPRT结合的作用尚待确定。结论：已经制定了这些共识性指南，为高危前列腺切除术后患者的放射肿瘤学家和泌尿科医师提供临床和技术指导。

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