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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >MRI before and after external beam intensity-modulated radiotherapy of patients with prostate cancer: the feasibility of monitoring of radiation-induced tissue changes using a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence.
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MRI before and after external beam intensity-modulated radiotherapy of patients with prostate cancer: the feasibility of monitoring of radiation-induced tissue changes using a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence.

机译：前列腺癌患者外部束强度调制放射治疗前后的MRI：使用动态对比增强型反转制备的双对比度梯度回波序列监测放射线诱发的组织变化的可行性。

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PURPOSE: To identify and quantify suitable pharmacokinetic MRI parameters for monitoring tissue changes after external beam intensity-modulated radiotherapy of prostate cancer. MATERIAL AND METHODS: Six patients with biopsy-proven prostate cancer (initial PSA, 6.0-81.4 ng/ml) underwent MRI at 1.5 T using a combined endorectal/body phased-array coil and a dynamic contrast-enhanced inversion-prepared dual-contrast gradient echo sequence (T1/T2(*)w; 1.65 s temporal resolution). MRI was performed before and immediately after radiotherapy, at 3 months and at 1 year. Perfusion, blood volume, mean transit time, delay, dispersion, interstitial volume, and extraction coefficient were calculated in prostate cancer and normal prostate for all four time points using a sequential 3-compartment model. RESULTS: Prostate cancer and normal prostate tissue showed a statistically significant decrease in perfusion (p=0.006, p=0.001) and increase in extraction coefficient (p=0.004, p<0.001). For prostate cancer, there was also a decrease in vascular volume (p=0.034). The other parameters investigated showed no statistically significant changes. Statistically significant differences between prostate cancer and normal prostate tissue were only observed before radiotherapy, when prostate cancer showed significantly higher perfusion (1.84 vs. 0.12 ml/cm(3)min, p=0.028) and a smaller extraction coefficient (0.42 vs. 0.64, p=0.028). CONCLUSIONS: Two pharmacokinetic parameters, perfusion and extraction coefficient, appear to be suitable candidates for monitoring the response to percutaneous intensity-modulated radiotherapy of prostate cancer.
机译：目的：鉴定和量化合适的药代动力学MRI参数，以监测前列腺癌的外部束强度调制放疗后的组织变化。材料与方法：6例经活检证实为前列腺癌（初始PSA，6.0-81.4 ng / ml）的患者在直肠癌/体内相控阵线圈和动态对比增强倒置双重对比技术的支持下于1.5 T接受MRI梯度回波序列（T1 / T2（*）w; 1.65 s时间分辨率）。在放疗之前和之后，3个月和1年进行MRI。使用连续三室模型，在所有四个时间点计算前列腺癌和正常前列腺的灌注，血容量，平均通过时间，延迟，分散，间隙体积和提取系数。结果：前列腺癌和正常前列腺组织显示出统计学显着的灌注减少（p = 0.006，p = 0.001）和提取系数增加（p = 0.004，p <0.001）。对于前列腺癌，血管体积也减少（p = 0.034）。研究的其他参数显示无统计学显着变化。仅在放疗前观察到前列腺癌与正常前列腺组织之间的统计学显着差异，当时前列腺癌显示出明显更高的灌注（1.84 vs. 0.12 ml / cm（3）min，p = 0.028）和较小的提取系数（0.42 vs. 0.64 ，p ＝ 0.028）。结论：灌注和提取系数这两个药代动力学参数似乎是监测前列腺癌经皮强度调节放疗反应的合适候选者。

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