...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Correlation of dose-volume parameters, endoscopic and clinical rectal side effects in cervix cancer patients treated with definitive radiotherapy including MRI-based brachytherapy.
【24h】

Correlation of dose-volume parameters, endoscopic and clinical rectal side effects in cervix cancer patients treated with definitive radiotherapy including MRI-based brachytherapy.

机译：接受确定性放疗（包括基于MRI的近距离放射治疗）治疗的宫颈癌患者的剂量-体积参数，内镜和临床直肠副作用的相关性。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: Correlation of dosimetric parameters for MRI-based 3D treatment planning with rectoscopic findings and clinical rectal side effects. METHODS AND MATERIALS: Rectosigmoidoscopy and rectal morbidity assessment were performed on 35 cervical cancer patients treated with external beam radiotherapy (EBRT) and HDR-intracavitary brachytherapy (ICB). The total doses, normalised to 2 Gy fractions (EQD2, alpha/beta=3 Gy), in 0.1, 1.0 and 2.0 cm(3) (D(0.1 cc), D(1 cc), D(2 cc)) of rectum were determined by summation of EBRT and ICB plans. Correlation analysis between clinical symptoms (LENT/SOMA) and rectoscopic changes (Vienna Rectoscopy Score, VRS) was performed. For dose-response analyses, the logit model was applied. RESULTS: Mean follow-up was 18 months. LENT/SOMA score was 1 in 4 patients, 2 in 8 patients, 4 in 1 patient. Telangiectasia was found in 26 patients (74%), five of them had ulceration corresponding to the 0.1 cm(3) volume (anterior wall). Mean values D(0.1 cc), D(1 cc), and D(2 cc) were 81+/-13, 70+/-9 and 66+/-8 Gy, respectively. The ED50 values for VRS > or = 3 and for LENT/SOMA > or = 2 significantly increased with decreasing volumes. D(2 cc) was higher in patients with VRS > or = 3 compared to VRS<3 (72+/-6 vs 62+/-7 Gy; p<0.001) and in symptomatic vs asymptomatic patients (72+/-6 vs 63+/-8 Gy; p<0.001). VRS correlated with the LENT/SOMA score. CONCLUSIONS: Rectosigmoidoscopy is sensitive in detecting mucosal changes, independent of clinical symptoms. The localization of these changes corresponds to the high dose volumes as defined by imaging. The development of mucosal and clinical changes in the rectum follows a clear dose-effect and volume-effect. DVH parameters could be established.
机译：目的：基于MRI的3D治疗计划的剂量参数与直肠镜检查结果和临床直肠副作用的相关性。方法与材料：对35例宫颈癌患者进行了直肠乙状结肠镜检查和直肠疾病的评估，这些患者接受了体外放射治疗（EBRT）和HDR-鼻腔近距离放射治疗（ICB）。在0.1、1.0和2.0 cm（3）（D（0.1 cc），D（1 cc），D（2 cc））中将总剂量标准化为2 Gy分数（EQD2，alpha / beta = 3 Gy）直肠由EBRT和ICB计划的总和决定。进行临床症状（LENT / SOMA）与直肠镜检查变化（维也纳直肠镜评分，VRS）之间的相关性分析。对于剂量反应分析，应用了logit模型。结果：平均随访18个月。 LENT / SOMA评分为4名患者中的1名，8名患者中的2名，1名患者中的4名。毛细血管扩张症发现于26例患者中（74％），其中五人有溃疡，其溃疡体积为0.1 cm（3）（前壁）。平均值D（0.1 cc），D（1 cc）和D（2 cc）分别为81 +/- 13、70 +/- 9和66 +/- 8 Gy。 VRS>或= 3且LENT / SOMA>或= 2的ED50值随着体积的减小而显着增加。 VRS>或= 3的患者的D（2 cc）高于VRS <3（72 +/- 6 vs 62 +/- 7 Gy; p <0.001）以及有症状和无症状患者（72 +/- 6） vs 63 +/- 8 Gy; p <0.001）。 VRS与LENT / SOMA得分相关。结论：直肠乙状结肠镜检查对粘膜变化敏感，与临床症状无关。这些变化的定位对应于通过成像定义的高剂量体积。直肠粘膜的发展和临床变化遵循明显的剂量效应和体积效应。可以建立DVH参数。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号