Does Smad6 methylation control BMP signaling in cancer?

XuJ.; DerynckR.

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Does Smad6 methylation control BMP signaling in cancer?

机译：Smad6甲基化可控制癌症中的BMP信号传导吗？

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Bone morphogenetic proteins (BMPs), a class of secreted TGF-beta-related proteins, play key roles in many cell differentiation decisions in metazoan development. BMP signaling is dysregulated in developmental syndromes and contributes to progressive diseases, including cancers. BMP ligands activate signaling responses through tetrameric complexes consisting of 2 type II (RII) and 2 type I (RI) transmembrane receptor kinases. Ligand binding induces RII receptors to phosphorylate and activate RI receptors, and these then activate the intracellu-lar effectors Smad1 and Smad5 through C-terminal serine phosphorylation, which stands in contrast to activation of Smad2 and Smad3 by TGF-betas and activins.

机译：骨形态发生蛋白（BMP）是一类与TGF-β相关的分泌蛋白，在后生动物发育的许多细胞分化决定中起着关键作用。 BMP信号在发育综合征中失调，并导致包括癌症在内的进行性疾病。 BMP配体通过由2种II型（RII）和2种I型（RI）跨膜受体激酶组成的四聚体复合物激活信号传导反应。配体结合诱导RII受体磷酸化并激活RI受体，然后这些受体通过C端丝氨酸磷酸化激活细胞内效应子Smad1和Smad5，这与TGF-betas和激活素激活Smad2和Smad3相反。

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《Cell cycle》 |2014年第8期|共2页
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XuJ.; DerynckR.;
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正文语种 eng
中图分类细胞生物学;
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1. Does Smad6 methylation control BMP signaling in cancer? [J] . XuJ., DerynckR. Cell cycle . 2014,第8期

机译：Smad6甲基化可控制癌症中的BMP信号传导吗？
2. BMP signalling controls the malignant potential of ascites-derived human epithelial ovarian cancer spheroids via AKT kinase activation. [J] . Teresa M Peart, Rohann J M Correa, Yudith Ramos Valdes, Clinical and experimental metastasis . 2012,第4期

机译：BMP信号通过AKT激酶激活控制腹水来源的人上皮性卵巢癌球体的恶性潜能。
3. BMP signalling controls the malignant potential of ascites-derived human epithelial ovarian cancer spheroids via AKT kinase activation [J] . Teresa M. Peart, Rohann J. M. Correa, Yudith Ramos Valdes, Clinical and Experimental Metastasis . 2012,第4期

机译：BMP信号通过AKT激酶激活控制腹水来源的人上皮性卵巢癌球体的恶性潜能
4. PTM Profiling of Cancer Cells by Sequential Enrichment for Methylation, Acetylation and Phosphorylation to Monitor Cellular Signaling Upon Adenosine-2',3'-Dialdehyde Treatment [C] . Ghaith Hamza, Charles L. Farnsworth, Hongbo Gu, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：通过顺序富集甲基化，乙酰化和磷酸化，以监测腺苷-2'，3'-二醛处理的细胞信号传导的PTM谱分析
5. Control of breast cancer cell migration, proliferation, and epithelial to mesenchymal transition by regulator of G protein signaling (RGS3) [D] . Sethakorn, Nan 2012

机译：通过调节G蛋白信号（RGS3）来控制乳腺癌细胞的迁移，增殖和上皮向间质转化
6. Does Smad6 methylation control BMP signaling in cancer? [O] . Jian Xu, Rik Derynck 2014

机译：Smad6甲基化可控制癌症中的BMP信号传导吗？
7. 280 – Inhibitory Smad6 Reduces Sox9 Expression in Esophageal Squamous and Barrett's Epithelial Cells: Potential Role for Canonical Bmp4 Signaling in Barrett's Pathogenesis [O] . Yuji Tamagawa, Thai Pham, Norihisa Ishimura, 2019

机译：280 - 抑制SMAD6减少食管鳞状和巴雷特上皮细胞中的SOX9表达：在Barrett的发病机制中规范BMP4信号传导的潜在作用

Does Smad6 methylation control BMP signaling in cancer?

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