...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Feasibility of applying a single treatment plan for both fractions in PDR image guided brachytherapy in cervix cancer
【24h】

Feasibility of applying a single treatment plan for both fractions in PDR image guided brachytherapy in cervix cancer

机译：在子宫颈癌的PDR图像引导近距离放射治疗中对这两个部分应用单一治疗计划的可行性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Purpose: This study explores the feasibility of limiting dose optimisation to the first brachytherapy fraction (BT1) and applying the same plan for the second fraction (BT2). Material and methods: Seventy one consecutive patients were analysed. Pulsed dose rate (PDR) BT was initiated after about 4 weeks of external beam radiotherapy (EBRT). Thirty eight patients had only intracavitary applicator (IC), and 33 had combined IC with interstitial needles (IC/IS). The optimised BT1 plan was copied to BT2 images with no further optimisation (single plan scenario) and dose volume histogram (DVH) parameters were compared with those of full dose optimisation for every fraction (optimised plan scenario). Results: 31/38 IC patients had similar applicator geometry in both fractions and mean DVH parameters were comparable between full optimisation and single plan. The mean HR CTV D90 in total EQD2 with optimisation was 94.5 Gy and with single plan scenario was 94.4 Gy (p = 0.89). Organs at risk (OARs) planning aims were fulfilled with the single plan, although 5/31 patients would receive 3-10 Gy extra to the D2cm 3. The mean doses in total EQD2 for the D2cm 3 of the bladder, rectum, sigmoid and bowel were respectively 68.5, 61.0, 64.9 and 60.6 Gy for the optimised plan, and for the single plan scenario were 69.0, 61.3, 65.1 and 60.8 Gy respectively. The difference was statistically not significant. The standard deviation (SD) of the difference between the single plan and the optimised plan was 3.2 Gy for HR CTV and 2.9, 1.4, 1.2, 1.6 Gy for the bladder, rectum, sigmoid and bowel D2 cm 3, respectively. Only 4/33 IC/IS patients had the same applicator geometry and single plan was therefore not feasible for the majority of these patients. Conclusion: For IC BT in small volume tumours (primarily stage IB-IIB) with mean HR CTV volume at BT1 = 24 ± 12 cm3, comparable mean DVH parameters resulted when applying a single plan, but with considerable variations in individual patients. Yet since in our population the applied target doses are high and the OARs doses are lower than the dose volume constraints these variations may not have considerable clinical consequences. Individual optimisation for each BT fraction is recommended when interstitial needles are used.
机译：目的：本研究探讨了将剂量优化限制在第一个近距离放射治疗部分（BT1）并针对第二个部分（BT2）应用相同计划的可行性。材料和方法：连续分析71例患者。在约4周的外部束放射治疗（EBRT）后开始脉冲剂量率（PDR）BT。 38例患者仅使用腔内涂药器（IC），33例将IC与组织间穿刺针结合使用（IC / IS）。将优化的BT1计划复制到BT2图像中，而无需进一步优化（单一计划方案），并且将剂量体积直方图（DVH）参数与每个部分的全剂量优化参数进行比较（优化计划方案）。结果：31/38的IC患者在两个部分中的涂药器几何形状均相似，并且平均DVH参数在完全优化和单一计划之间具有可比性。优化后的总EQD2的平均HR CTV D90为94.5 Gy，单计划方案为94.4 Gy（p = 0.89）。尽管有5/31的患者在D2cm 3处将额外获得3-10 Gy的风险，但单一计划已实现了危险器官（OARs）规划的目标。优化计划的肠胃分别为68.5、61.0、64.9和60.6 Gy，而单一计划方案的肠胃分别为69.0、61.3、65.1和60.8 Gy。差异在统计学上不显着。 HR CTV的单个计划和优化计划之间的差异的标准偏差（SD）为3.2 Gy，膀胱，直肠，乙状结肠和肠D2 cm 3分别为2.9、1.4、1.2、1.6 Gy。只有4/33的IC / IS患者具有相同的涂抹器几何形状，因此对于大多数这些患者而言，单一计划是不可行的。结论：对于小体积肿瘤（主要为IB-IIB期）的IC BT，其BT1 = 24±12 cm3的平均HR CTV体积，采用单一计划时可得到相当的DVH参数，但个体患者的差异很大。然而，由于在我们的人群中，所施加的目标剂量较高，而OARs剂量低于剂量体积限制，因此这些变化可能不会产生重大的临床后果。当使用间隙针时，建议针对每个BT分数进行单独优化。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号