Initial assessment of tumor tracking with a gimbaled linac system in clinical circumstances: A patient simulation study

DepuydtT.; PoelsK.; VerellenD.; EngelsB.; CollenC.; HaverbekeC.; GevaertT.; BulsN.; VanGompelG.; ReyndersT.; DuchateauM.; TournelK.; BoussaerM.; SteenbekeF.; VandenbrouckeF.; DeRidderM.

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Initial assessment of tumor tracking with a gimbaled linac system in clinical circumstances: A patient simulation study

机译：用万向节直线加速器系统在临床情况下对肿瘤追踪的初步评估：一项患者模拟研究

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Purpose: To have an initial assessment of the Vero Dynamic Tracking workflow in clinical circumstances and quantify the performance of the tracking system, a simulation study was set up on 5 lung and liver patients. Methods and materials: The preparatory steps of a tumor tracking treatment, based on fiducial markers implanted in the tumor, were executed allowing pursuit of the tumor with the gimbaled linac and monitoring X-rays acquisition, however, without activating the 6 MV beam. Data were acquired on workflow time-efficiency, tracking accuracy and imaging exposure. Results: The average time between the patient entering the treatment room and the first treatment field was about 9 min. The time for building the correlation model was 3.2 min. Tracking errors of 0.55 and 0.95 mm (1σ) were observed in PAN/TILT direction and a 2D range of 3.08 mm. A skin dose was determined of 0.08 mGy/image, with a source-to-skin distance of 900 mm and kV exposure of 1 mAs. On average 1.8 mGy/min kV skin dose was observed for 1 Hz monitoring. Conclusion: The Vero tracking solution proved to be fully functional and showed performance comparable with other real-time tracking systems.

机译：目的：为了对临床环境中的Vero动态跟踪工作流程进行初步评估并量化跟踪系统的性能，我们对5名肺和肝患者进行了模拟研究。方法和材料：基于植入在肿瘤中的基准标记，执行了肿瘤追踪治疗的准备步骤，从而允许使用万向节直线加速器追赶肿瘤并监控X射线的采集，但是并没有激活6 MV射束。获取有关工作流程时间效率，跟踪精度和成像曝光的数据。结果：患者进入治疗室与首次治疗场之间的平均时间约为9分钟。建立相关模型的时间为3.2分钟。在PAN / TILT方向上观察到的跟踪误差为0.55和0.95 mm（1σ），二维范围为3.08 mm。确定皮肤剂量为0.08 mGy /图像，源到皮肤距离为900 mm，kV暴露为1 mAs。对于1 Hz监测，平均观察到1.8 mGy / min kV皮肤剂量。结论：Vero跟踪解决方案被证明是功能齐全的，并具有与其他实时跟踪系统相当的性能。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2013年第2期|共5页
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DepuydtT.; PoelsK.; VerellenD.; EngelsB.; CollenC.; HaverbekeC.; GevaertT.; BulsN.; VanGompelG.; ReyndersT.; DuchateauM.; TournelK.; BoussaerM.; SteenbekeF.; VandenbrouckeF.; DeRidderM.;
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正文语种 eng
中图分类肿瘤学;
关键词
Organ motion; Stereotactic body radiation therapy; Tumor tracking;

机译：器官运动;立体定向放射治疗;肿瘤追踪;

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1. Initial assessment of tumor tracking with a gimbaled linac system in clinical circumstances: A patient simulation study [J] . DepuydtT., PoelsK., VerellenD., Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2013,第2期

机译：用万向节直线加速器系统在临床情况下对肿瘤追踪的初步评估：一项患者模拟研究
2. Treating patients with real-time tumor tracking using the Vero gimbaled linac system: Implementation and first review [J] . Depuydt Tom, Poels Kenneth, Verellen Dirk, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2014,第3期

机译：使用Vero万向节直线加速器系统实时跟踪肿瘤的患者：实施和首次审核
3. Dynamic System Simulation for Prediction of the Number of Patients with Malignant Tumors in Various Clinical Groups and Assessment of the Demand for Financial Resources [J] . L. Ya. Bukharbaeva, I. R. Rakhmatullina, M. V. Tanyukevich Biomedical engineering . 2004,第2期

机译：动态系统仿真，用于预测各个临床组的恶性肿瘤患者人数并评估财务资源需求
4. Development of four-dimensional Monte Carlo dose calculation system for dynamic tumor-tracking irradiation with a gimbaled X-ray head [C] . Y. Ishihara, A. Sawada, Y. Miyabe, World Congress on Medical Physics and Biomedical Engineering . 2013

机译：用万向X射线头动态跟踪肿瘤的二维Monte Carlo剂量计算系统的开发
5. DESIGN OF AN INTEGRATED FLIGHT/FIRE CONTROL SYSTEM INCLUDING MOVABLE GUN AND GIMBALED LINE OF SIGHT TRACKER. [D] . BLAKELOCK, JOHN HAZEN. 1979

机译：飞行器和火炮综合瞄准线的飞行/火控一体化系统的设计。
6. Simple quality assurance method of dynamic tumor tracking with the gimbaled linac system using a light field [O] . Hideharu Miura, Shuichi Ozawa, Masahiro Hayata, 2016

机译：利用万向节直线加速器系统利用光场动态跟踪肿瘤的简单质量保证方法
7. MODERATED EPOSTERS1385Longitudinal strain assessment in dilated cardiomyopathy patients using a novel accelerated DENSE sequence1407Simultaneous T1 and T2 cardiac quantification with CABIRIA: initial clinical experience1423Head-to-head comparison of acceleration algorithms in 4-dimensional flow CMR1502Left ventricular function and size evaluated by hybrid cardiac positron emission tomography-magnetic resonance: Intraindividual comparison of left ventricular ejection fraction and ventricular volumes derived by two modalities1510Left Atrium assessed by Cardiovascular Magnetic Resonance at 1.5 and 3 Tesla – age and gender effects1514Comparison of Free Breathing Cardiac MRI Radial technique to the Standard Multi breath-hold cine SSFP CMR technique for the assessment of LV Volumes and Function1536Self-navigated free-breathing isotropic 3D whole heart phase sensitive inversion recovery magnetic resonance without navigator for detection of myocardial infarction1547Assessment of Right Ventricular Strain Using Myocardial Deformation Recovery Semi Automated Technique: Initial Experience and Normal Values1586Tissue tracking myocardial deformation analysis and prediction of left ventricular remodeling in acute myocardial infarction1589Investigating strategies for optimal 31P MRS clinical cardiac at 3T: Initial Results1620Quantitative Criteria for the Diagnosis of the Congenital Absence of Pericardium by Cardiac Magnetic Resonance1632Widespread tissue injury during acute myocardial infarction: evidence from advanced CMR relaxometry1322Computed tomography coronary angiography verSus sTRess cArdiac magneTic rEsonance for the manaGement of sYmptomatic revascularized patients: a cost effectiveness study (STRATEGY study)1339Comparison of low- versus high-dose of gadobutrol for late gadolinium enhancement imaging at 1.5 Tesla: a clinical feasibility study1347Multi-parametric Cardiac Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Intermedia: a Prospective Multicenter Study1461Prognostic value of Cardiovascular Magnetic Resonance derived indexes of myocardial fibrosis in heart transplant recipients1523The role of CMR in the acute phase of hospitalization: changing paradigms1542Preoperative CMR-based score predict ventricular response after surgical left ventricular reconstruction in ischemic heart failure patients1555Excellent response rate to cardiac resynchronization therapy guided with magnetic resonance imaging1626The ECG as a predictor of arrhythmogenic substrate on Cardiac Magnetic Resonance Imaging in patients undergoing ablation for premature ventricular contractions1649Comparison of T1-mapping at 3.0T CMR and angiographic APPROACH score for area at risk assessment in ST-segment elevation myocardial infarction1340Pathological correlates of left bundle branch disease in patients with non-ischemic cardiomyopathy: a cardiovascular magnetic resonance study1342Myocardial remodelling and fibrosis in nonischaemic dilated cardiomyopathy: insights from cardiovascular magnetic resonance1411The association between fibrosis and contractile dysfunction in hypertrophic cardiomyopathy assessed by cardiovascular magnetic resonance1622Persistent myocardial inflammation due to intramyocardial haemorrhage in reperfused STEMI as a precursor to adverse LV remodelling - insights from multi-parametric mapping1566Semiquantitative analysis of low and high b value DWI for detecting myocardial edema in acute myocarditis1567Value of Cardiac MRI In Detecting Coronary Artery Disease In Newly Diagnosed Systolic Dysfunction1570Usefulness of cardiac magnetic resonance in tuberous sclerosis complex1578Papillary muscles offer further insight into hypertrophied hearts: a cardiovascular magnetic resonance study1627Diagnostic and clinical implications of CMR timing (early versus late) in patients with troponin positive acute coronary syndromes and unobstructed coronary arteries: Table 1. [O] . Upasana Tayal, Alexandros Kallifatidis, P. Garg, 2016

机译：在使用新的扩张型心肌病的患者缓和EPOSTERS1385Longitudinal应变评估加速DENSE sequence1407Simultaneous T1和T2与CABIRIA心脏定量：在4维流动的加速算法初始临床experience1423Head对头比较CMR1502Left心室功能和尺寸由混合心脏正电子发射断层摄影术评价 - 磁性共振：由两个modalities1510Left庭派生左室射血分数和心室体积的个体间的比较，在1.5和3特斯拉评估心血管磁共振 - 免费的年龄和性别effects1514Comparison呼吸心脏MRI径向技术标准的多屏气电影SSFP CMR技术的LV卷和Function1536Self-导航自由呼吸各向同性3D整个心脏相位敏感反转恢复磁共振导航仪没有检测右Ventricu心肌infarction1547Assessment的评估拉尔菌株使用心肌变形恢复半自动技术：初步经验和正常Values1586Tissue跟踪心肌变形分析和预测左室重构急性心肌infarction1589Investigating策略优化31P MRS临床心脏在3T：初始Results1620Quantitative标准的先天缺失的诊断心包心脏磁Resonance1632Widespread组织损伤急性心肌梗死时：证据先进CMR relaxometry1322Computed CT冠状动脉成像与压力心脏磁共振对症的管理吻合血管患者：成本效益研究（战略研究）1339Comparison低与高剂量钆布醇在1.5特斯拉晚钆增强成像的临床可行性，在中间型地贫心脏并发症的预测study1347Multi参数心脏核磁共振的前瞻性德穆尔心血管磁共振的ticenter Study1461Prognostic价值衍生心肌纤维化指标在住院的急性期CMR的心脏移植recipients1523The作用：改变基于CMR-paradigms1542Preoperative比分预测缺血性心脏衰竭patients1555Excellent响应速度外科左心室重建心脏再同步化后心室反应治疗与磁共振imaging1626The ECG导引作为心脏磁共振成像致心律失常性基板的在ST段抬高心肌infarction1340Pathological在风险评估经历在3.0T CMR T1映射的室性早搏contractions1649Comparison和血管造影APPROACH分数区域消融患者的预测左束支传导疾病的患者与非缺血性心肌病相关因素：心血管磁共振study1342Myocardial重塑和纤维化nonischaemic扩张型心肌病：在从在由心血管磁性resonance1622Persistent心肌炎症评估肥厚型心肌病的纤维化和收缩功能障碍之间心血管磁性resonance1411The协会由于心肌内出血景点在再灌注STEMI为先导，以不利的LV重塑 - 从低的多参数mapping1566Semiquantitative分析和高的b值DWI的见解为在心脏MRI检测冠状动脉疾病急性myocarditis1567Value在结节性硬化症complex1578Papillary肌肉初诊收缩期Dysfunction1570Usefulness心脏磁共振检测心肌水肿提供进一步的深入了解肥大心脏：心血管磁共振study1627Diagnostic和CMR定时的临床意义（早期与晚）患者肌钙蛋白阳性的急性冠脉综合征和通畅的冠状动脉：表1。
8. Studies of biologic activation associated with molecular receptor increase and tumor response in ChL6/L6 protocol patients; Studies in phantoms; Quantitative SPECT; Preclinical studies; and Clinical studies. DOE annual report, 1994--95 [R] . DeNardo, S. J. 1995

机译：研究ChL6 / L6方案患者的分子受体增加和肿瘤反应相关的生物活化;幽灵研究;定量spECT;临床前研究;和临床研究。美国能源部年度报告，1994年至1995年

Initial assessment of tumor tracking with a gimbaled linac system in clinical circumstances: A patient simulation study

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