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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Intensity-modulated radiation therapy in head and neck cancer: Prescribed dose, clinical challenges and results.
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Intensity-modulated radiation therapy in head and neck cancer: Prescribed dose, clinical challenges and results.

机译：头颈部癌的调强放射疗法：处方剂量，临床挑战和结果。

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摘要

Purpose. To analyse clinical and dosimetric characteristics with regard to clinical constraints in head and neck cancer patients treated with intensity-modulated radiotherapy (IMRT). Materials and methods. Between August 2001 and July 2005, 75 patients with non-metastatic head and neck cancers were treated with IMRT with curative intent. Dose-volume histograms (DVH) drawn up from inverse dosimetry were analysed and compared to the prescription according to the clinical presentation of the disease. Results. For bilateral irradiation, the mean doses delivered to the contralateral and ipsilateral parotid glands were, respectively, 28.1 and 26.3Gy. Dose constraints to the submandibular glands were only respected for the contralateral gland during unilateral irradiation. For tumors located in paranasal sinuses, the maximal dose to the contralateral and ipsilateral optic nerves remained significantly lower than the constraint doses while the constraints for the anterior part of the eyes could not be respected. Conclusions. Significant differences were observed concerning respect of the constraints applied to the parotid or to the submandibular glands for medial tumors. The respect of constraints for the organs at risk critically depends on the location and size of the primary tumor and on the definition of the CTV. The clinical impact has to be further evaluated.
机译：目的。分析用强度调制放疗（IMRT）治疗的头颈癌患者的临床约束方面的临床和剂量学特征。材料和方法。在2001年8月至2005年7月之间，对75例非转移性头颈癌患者进行了IMRT根治性治疗。根据疾病的临床表现，对通过反剂量​​法绘制的剂量-体积直方图（DVH）进行分析并与处方进行比较。结果。对于双侧照射，传递到对侧和同侧腮腺的平均剂量分别为28.1和26.3Gy。仅在单侧照射期间考虑对侧腺对下颌下腺的剂量限制。对于位于鼻旁窦的肿瘤，对侧和同侧视神经的最大剂量仍显着低于约束剂量，而对眼前部的约束则不予考虑。结论在针对腮腺或下颌下腺对内侧肿瘤施加的约束方面，观察到了显着差异。对处于危险中的器官的约束条件的尊重主要取决于原发肿瘤的位置和大小以及CTV的定义。临床影响必须进一步评估。

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