Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation.

Supiot S; Thillays F; Rio E; Gouard S; Morgenstern A; Bruchertseifer F; Mahe MA; Chatal JF; Davodeau F; Cherel M

首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation.

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Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation.

机译：吉西他滨使多发性骨髓瘤细胞对低辐射（而不是高辐射）辐射敏感。

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The radiosensitizing properties of gemcitabine in relation to low Linear Energy Transfer (LET) particles (Cobalt 60) and high-LET particles (alpha-RIT (213)Bi-radiolabeled CHX-DTPA-B-B4) were analyzed. Three multiple myeloma cell lines (LP1, RPMI 8226, U266) were irradiated with or without 10 nM gemcitabine 24 h prior to radiation. Gemcitabine led to radiosensitization of LP1 and U266 cells with low-LET (Radiation Enhancement Ratio: 1.55 and 1.49, respectively) but did not radiosensitize any cell line when combined with high-LET.

机译：分析了吉西他滨相对于低线性能量转移（LET）粒子（钴60）和高LET粒子（α-RIT（213）Bi-放射性标记的CHX-DTPA-B-B4）的放射增敏特性。在辐射前24小时，用或不用10 nM吉西他滨照射三种多发性骨髓瘤细胞系（LP1，RPMI 8226，U266）。吉西他滨以低LET导致LP1和U266细胞放射增敏（辐射增强比分别为1.55和1.49），但与高LET结合使用时未对任何细胞系进行放射增敏。

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来源
《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2007年第1期|共5页
作者
Supiot S; Thillays F; Rio E; Gouard S; Morgenstern A; Bruchertseifer F; Mahe MA; Chatal JF; Davodeau F; Cherel M;
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正文语种 eng
中图分类放射医学;肿瘤学;
关键词
Linear Energy Transfer; gemcitabine; multiple myeloma and other plasma cell neoplasms; 传能线密度; 辐射;

机译：Linear Energy Transfer;gemcitabine;multiple myeloma and other plasma cell neoplasms;传能线密度;辐射;

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1. Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation. [J] . Supiot S, Thillays F, Rio E, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2007,第1期

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Gemcitabine radiosensitizes multiple myeloma cells to low let, but not high let, irradiation.

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