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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Transient neurological adverse effects following low dose radiation therapy for early stage testicular seminoma.
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Transient neurological adverse effects following low dose radiation therapy for early stage testicular seminoma.

机译：低剂量放射治疗后早期睾丸精原细胞瘤的短暂神经系统不良反应。

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摘要

BACKGROUND AND PURPOSE: The aim of this study was to estimate the rate of neurological adverse effects following radiotherapy for testicular seminoma and to disclose possible dose-related effects. PATIENTS AND METHODS: All seminoma patients (n=346) treated 1980-2001 at our department with radiotherapy as the only treatment modality following orchiectomy constitute the study group (median follow-up 10 years). Since 1980, clinical data including possible side effects have systematically been recorded in these patients. These records were used to identify men with possible neurological adverse effects. Univariate logistic regression was used to estimate dose-related effects. RESULTS: Overall, 11 men (3.2%) with neurological symptoms probably related to radiotherapy were identified. Seven men treated with 25.2-36 Gray presented with sensory symptoms about 2 months following radiotherapy. These symptoms resolved in all but one after 1-3 months. The remaining four men (dose 36-40 Gray) had motor impairment which lasted at least one year, but none had persistent pareses at long-term follow-up. There was a statistically significant (p=0.02) increase in rate of motor symptoms with higher dose. CONCLUSIONS: Although motor impairment is unlikely to occur at current standard doses for seminomas, physicians should be ware of the sensory symptoms these men may exhibit.
机译：背景与目的：本研究的目的是评估睾丸精原细胞瘤放疗后神经系统不良反应的发生率，并揭示可能的剂量相关作用。患者与方法：所有精原细胞瘤患者（n = 346）在我科接受放疗治疗，在睾丸切除术后唯一的治疗方式为1980-2001年，是研究组（中位随访10年）。自1980年以来，已在这些患者中系统记录了包括可能的副作用在内的临床数据。这些记录用于识别可能造成神经系统不良反应的男性。单因素逻辑回归用于估计剂量相关的影响。结果：总体上，确定了11名男性（3.2％）的神经系统症状可能与放疗有关。放疗后约2个月，接受25.2-36 Gray治疗的7名男性出现了感官症状。这些症状在1-3个月后几乎全部消失。其余四名男子（剂量为36至40格雷）患有运动障碍，持续至少一年，但在长期随访中均未出现持续性运动障碍。较高剂量的运动症状发生率有统计学上的显着性提高（p = 0.02）。结论：尽管在目前标准剂量的精原细胞瘤中不太可能发生运动障碍，但医生应注意这些男性可能表现出的感觉症状。

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