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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Comparison of 6 MV and 18 MV photons for IMRT treatment of lung cancer.
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Comparison of 6 MV and 18 MV photons for IMRT treatment of lung cancer.

机译：IMRT治疗肺癌的6 MV和18 MV光子的比较。

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摘要

BACKGROUND AND PURPOSE: To compare 6 MV and 18 MV photon intensity modulated radiotherapy (IMRT) for non-small cell lung cancer. MATERIALS AND METHODS: Doses for a cohort of 10 patients, typical for our department, were computed with a commercially available convolution/superposition (CS) algorithm. Final dose computation was also performed with a dedicated IMRT Monte Carlo dose engine (MCDE). RESULTS: CS plans showed higher D(95%) (Gy) for the GTV (68.13 vs 67.36, p=0.004) and CTV (67.23 vs 66.87, p=0.028) with 18 than with 6 MV photons. MCDE computations demonstrated higher doses with 6 MV than 18 MV in D(95%) for the PTV (64.62 vs 63.64, p=0.009), PTV(optim) (65.48 vs 64.83, p=0.014) and CTV (66.22 vs 65.64, p=0.027). Dose inhomogeneity was lower with 18 than with 6 MV photons for GTV (0.08 vs 0.09, p=0.007) and CTV (0.10 vs 0.11, p=0.045) in CS but not MCDE plans. 6 MV photons significantly (D(33%); p=0.045) spared the esophagus in MCDE plans. Observed dose differences between lower and higher energy IMRT plans were dependent on the individual patient. CONCLUSIONS: Selection of photon energy depends on priority ranking of endpoints and individual patients. In the absence of highly accurate dose computation algorithms such as CS and MCDE, 6 MV photons may be the prudent choice.
机译：背景与目的：比较6 MV和18 MV光子强度调制放射治疗（IMRT）对非小细胞肺癌的治疗作用。材料与方法：使用商业上可买到的卷积/叠加（CS）算法计算出10名患者的剂量，这是本部门的典型剂量。还使用专用的IMRT蒙特卡洛剂量引擎（MCDE）进行最终剂量计算。结果：CS计划显示GTV（68.13 vs 67.36，p = 0.004）和CTV（18.23 vs 66.87，p = 0.028）的D（95％）（Gy）高于6个MV光子。 MCDE计算显示，对于PTV（64.62 vs 63.64，p = 0.009），PTV（optim）（65.48 vs 64.83，p = 0.014）和CTV（66.22 vs 65.64， p = 0.027）。在CS中，GTV（0.08 vs 0.09，p = 0.007）和CTV（18）的剂量不均匀性低于6 MV光子，而MCDE计划中的剂量不均匀性更低（0.18 vs 0.11，p = 0.045）。在MCDE计划中，有6个MV光子显着（D（33％）; p = 0.045）免除了食道。低能量和高能量IMRT计划之间观察到的剂量差异取决于患者。结论：光子能量的选择取决于终点和个体患者的优先等级。在缺少诸如CS和MCDE的高精度剂量计算算法的情况下，谨慎选择6 MV光子。

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