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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Application of active breathing control in 3-dimensional conformal radiation therapy for hepatocellular carcinoma: the feasibility and benefit.
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Application of active breathing control in 3-dimensional conformal radiation therapy for hepatocellular carcinoma: the feasibility and benefit.

机译：主动呼吸控制在肝细胞癌3D立体适形放射治疗中的应用：可行性和益处。

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摘要

BACKGROUND AND PURPOSE: To investigate the feasibility and effectiveness of utilizing active breathing coordinator (ABC) in 3DCRT for HCC. MATERIALS AND METHODS: A dosimetric comparison between the free-breathing (FB) plan and ABC plan in HCC 3DCRT was performed. Set-up errors and reproducibility of diaphragm position using ABC were measured, and patients' acceptance was also recorded. RESULTS: From April 2005 to February 2007, 28 HCC were irradiated with ABC and they tolerated ABC well. The mean dose to normal liver was reduced from 16.9Gy in FB plan to 14.3Gy in ABC plan. PTV for ABC and FB plans were 529cm(3) and 781cm(3), respectively, and V(23) were reduced from 45% to 30%. The predicted incidences of radiation-induced liver disease by Lyman model were 1% and 2.5%, respectively, in favor of ABC plan. The systematic and random errors for the ABC and FB plans were 1.2mm vs. 4.7mm, 1.6mm vs. 3.5mm, and 1.8mm vs. 2.7mm, respectively, in cranio-caudal, anterior-posterior, and left-right directions. Theaverage intrafraction reproducibility of diaphragm position in cranio-caudal direction was 1.6mm, and the interfraction, 6.7mm. CONCLUSIONS: The utilization of ABC in HCC 3DCRT is feasible, and can reduce liver irradiation.
机译：背景与目的：探讨在3DCRT中使用主动呼吸协调器（ABC）进行肝癌的可行性和有效性。材料与方法：对HCC 3DCRT中的自由呼吸（FB）计划和ABC计划进行了剂量学比较。测量使用ABC的设置误差和隔膜位置的可重复性，并记录患者的接受程度。结果：从2005年4月到2007年2月，用ABC照射了28例HCC，它们对ABC的耐受性良好。正常肝的平均剂量从FB计划的16.9Gy降低到ABC计划的14.3Gy。 ABC和FB计划的PTV分别为529cm（3）和781cm（3），V（23）从45％降低到30％。 Lyman模型预测的辐射诱发肝病发生率分别为1％和2.5％，有利于ABC计划。在颅尾，左右前后方向上，ABC和FB计划的系统误差和随机误差分别为1.2mm对4.7mm，1.6mm对3.5mm和1.8mm对2.7mm。 。横diaphragm位置在颅尾方向的平均分数内再现性为1.6mm，而分数为6.7mm。结论：ACC在肝癌3DCRT中的应用是可行的，并可减少肝脏的放射。

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