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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The effect of planning algorithms in oesophageal radiotherapy in the context of the SCOPE 1 trial.
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The effect of planning algorithms in oesophageal radiotherapy in the context of the SCOPE 1 trial.

机译：在SCOPE 1试验的背景下，规划算法在食道放射治疗中的作用。

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BACKGROUND AND PURPOSE: In radiotherapy clinical trials multiple centres contribute to patient recruitment. Depending on the calculation algorithm used, the reported dose distributions may differ significantly: broadly, the results for algorithms which do not model lateral electron transport (type a) give less accurate results than the more recently available algorithms that do (type b) when compared to Monte Carlo simulations and measurements. Clinical implementation studies for type b algorithms have yet to be reported for oesophageal radiotherapy. Furthermore, clinical trials must ensure an equivalent effect of the treatment regardless of calculation method. This retrospective planning study aims to define guidance for type b planning in a UK oesophageal clinical trial, to enable acceptable consistency of dose distributions regardless of algorithm, and allow for the improved calculation accuracy of type b to be incorporated into the optimization. MATERIALS AND METHODS: Fifteen patient data sets were planned using a single type a algorithm. Plans were recalculated using a single type b algorithm and subsequently re-optimized with the type b in accordance with optimization rules. The changes in absolute dose at the point of prescription for type a were compared to the recalculated type b. Dose-volume data for organs at risk (OARs), and target volumes were compared, and the volume of the planning target volume (PTV) receiving 95% of the prescribed dose (V95%) was compared to the percentage of PTV overlapping with lung. RESULTS: Dose at the prescription point decreased by 0.69% on average (SD=0.71), p=0.0021, for type b compared to that for type a. For the re-optimized type b, the OAR doses corresponding to the trial dose-volume constraints were maintained within 1.0% of the type a levels on average. Reductions in the mean PTV V95% of 9.3% and 3.8% were observed for the recalculated and re-optimized type b plans, respectively, when compared to the mean PTV V95% for type a. For the re-optimized type b there is a correlation between PTV V95% and the percentage of PTV overlapping lung (R(2)=0.4979). CONCLUSIONS: Plan optimization with the type b algorithm results in improved PTV V95%. Using our suggested optimization rules, equivalent OAR doses can be maintained with both types. For type b, this requires a measured level of compromise to PTV in low density tissue, quantified by the relationship between PTV V95% and the percentage of PTV in lung.
机译：背景与目的：在放射治疗临床试验中，多个中心有助于患者招募。根据所使用的计算算法，所报告的剂量分布可能存在显着差异：广义上讲，不对侧向电子传输建模的算法（a型）的结果与最新的可用算法（b型）相比，得出的准确度较低蒙特卡洛模拟和测量。 b型算法的临床实施研究尚未报道用于食道放疗。此外，无论采用何种计算方法，临床试验都必须确保治疗效果相同。这项回顾性计划研究旨在为英国食道临床试验中的b型计划制定指南，以使剂量分布的可接受一致性（与算法无关），并允许将改进的b型计算准确性纳入优化之中。材料与方法：使用单一类型的算法计划了15个患者数据集。使用单个b型算法重新计算计划，然后根据优化规则使用b型重新优化。将a型处方时的绝对剂量变化与重新计算的b型进行比较。比较了处于危险中的器官（OAR）的剂量体积数据和目标体积，并将接受95％处方剂量（V95％）的计划目标体积（PTV）的体积与PTV与肺重叠的百分比进行了比较。结果：与a型相比，b型在处方点的剂量平均下降0.69％（SD = 0.71），p = 0.0021。对于重新优化的b型，与试验剂量限制相对应的OAR剂量平均保持在a型水平的1.0％以内。重新计算和重新优化的b型计划的平均PTV V95％分别降低了9.3％和3.8％，与a型的平均PTV V95％相比。对于重新优化的类型b，PTV V95％与PTV重叠肺的百分比之间存在相关性（R（2）= 0.4979）。结论：使用b型算法进行计划优化可提高PTV V95％。使用我们建议的优化规则，两种类型都可以维持等效的OAR剂量。对于b型，这需要对低密度组织中PTV的折衷水平进行测量，并通过PTV V95％与肺中PTV百分比之间的关系进行量化。

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