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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Patterns of local recurrence in locally advanced rectal cancer after intra-operative radiotherapy containing multimodality treatment.
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Patterns of local recurrence in locally advanced rectal cancer after intra-operative radiotherapy containing multimodality treatment.

机译：包含多模式治疗的术中放疗后局部晚期直肠癌的局部复发模式。

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BACKGROUND AND PURPOSE: The purpose of this study is to analyze the patterns of local recurrence (LR) after intra-operative radiotherapy (IORT) containing multimodality treatment of locally advanced rectal carcinoma (LARC). METHODS AND MATERIALS: Two hundred and ninety patients with LARC who underwent multimodality treatment between 1994 and 2006 were studied. For patients who developed LR, the subsite was classified into presacral, postero-lateral, lateral, anterior, anastomotic or perineal. Patient and treatment characteristics were related to subsite of LR. RESULTS: After 5years, 34 patients (13.2%) developed LR. The most prominent subsite of LR was the presacral subsite. 47% of the local recurrences occurred outside the IORT field. Most recurrences developed when IORT was given dorsally, while least occurred when IORT was given ventrally. Especially after dorsal IORT a high amount of infield recurrences were observed (6 of 8; 75%). In multi-variate analysis tumor distance of more than 5cm from the anal verge and a positive circumferential margin were associated with presacral local recurrence. CONCLUSIONS: Multimodality treatment is effective in the prevention of local recurrence in LARC. IORT application to the area most at risk is feasible and seems effective in the prevention of local recurrence. Dorsal tumor location results in unfavourable oncologic results.
机译：背景与目的：本研究的目的是分析术中放疗（IORT）包含局部晚期直肠癌（LARC）多模式治疗后的局部复发（LR）模式。方法和材料：研究了1994年至2006年间接受多模式治疗的290例LARC患者。对于发生LR的患者，该子部位可分为s前，后外侧，外侧，前，吻合或会阴。患者和治疗特点与LR的亚位有关。结果：5年后，有34例患者（13.2％）发生了LR。 LR最突出的亚部位是s前亚部位。 47％的局部复发发生在IORT领域之外。 IORT背侧给予多数复发，而IORT给予腹侧给予最少。尤其是在IORT背侧后，观察到大量的内野复发（8例中有6例; 75％）。在多变量分析中，距肛门边缘超过5cm的肿瘤距离和阳性的外周缘与s前局部复发有关。结论：多模式治疗可有效预防LARC局部复发。将IORT应用于危险最高的区域是可行的，并且似乎可以有效地预防局部复发。背侧肿瘤位置导致不良的肿瘤学结果。

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