• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Assessment of carotid artery dose in the treatment of nasopharyngeal cancer with IMRT versus conventional radiotherapy.
【24h】

Assessment of carotid artery dose in the treatment of nasopharyngeal cancer with IMRT versus conventional radiotherapy.

机译：与常规放疗相比，IMRT治疗鼻咽癌的颈动脉剂量评估。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

PURPOSE: To determine the radiation dose to the carotid artery in nasopharyngeal cancer patients treated with intensity-modulated radiotherapy (IMRT) and to compare it to the dose delivered by a conventional three-field (3F) technique. MATERIALS AND METHODS: Sixteen patients with nasopharyngeal cancer who were treated at UCSF with IMRT were selected for this analysis. 3F plans were reconstructed for comparison. The carotid arteries were retrospectively contoured, and the dose received by each of the 32 carotid arteries was determined for both IMRT and 3F plans. A subset of 8 patients with N0/N1 nodal disease was selected for IMRT replanning using additional constraints to reduce the dose to the arteries. RESULTS: Using the standard prescription doses for IMRT and 3F plans, the dose delivered to 95% of the tumor volume was significantly higher in the IMRT plans, reflecting the greater conformality of this technique. The median mean dose to the carotid arteries was 65.7Gy with IMRT vs. 58.4Gy with 3F (p<0.001). After the application of dose constraints to the carotid arteries, it was possible to reduce the mean carotid dose to 54Gy in the IMRT replans. CONCLUSIONS: IMRT achieves a higher tumoricidal dose and superior clinical target volume coverage, but results in an increase in the carotid artery dose as compared to conventional 3F technique. With careful IMRT planning, it is possible to constrain the carotid dose for a subset of patients with low-risk neck disease. Further study is necessary to quantify the long-term clinical impact of this intervention.
机译：目的：确定经强度调制放疗（IMRT）治疗的鼻咽癌患者颈动脉的放射剂量，并将其与传统的三场（3F）技术进行比较。材料与方法：选择16例经IMRT在UCSF接受治疗的鼻咽癌患者进行此项分析。重建了3F计划以进行比较。回顾性地绘制颈动脉轮廓，并针对IMRT和3F计划确定32个颈动脉中每一个的剂量。选择了8名N0 / N1淋巴结肿大患者中的一部分用于IMRT重新规划，使用其他限制条件以减少动脉剂量。结果：使用IMRT和3F计划的标准处方剂量，在IMRT计划中，达到95％肿瘤体积的剂量明显更高，这反映了该技术的更大整合性。 IMRT对颈动脉的中位平均剂量为65.7Gy，而3F对颈动脉的中值平均剂量为58.4Gy（p <0.001）。在对颈动脉施加剂量限制后，有可能在IMRT重新计划中将平均颈动脉剂量降低至54Gy。结论：与常规3F技术相比，IMRT可实现更高的杀伤剂量和更佳的临床目标体积覆盖率，但会导致颈动脉剂量增加。通过仔细的IMRT计划，有可能限制一部分低危颈部疾病患者的颈动脉剂量。有必要进行进一步的研究以量化该干预措施的长期临床影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号