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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Urinary toxicity after high dose intensity modulated radiotherapy as primary therapy for prostate cancer.
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Urinary toxicity after high dose intensity modulated radiotherapy as primary therapy for prostate cancer.

机译：高剂量强度调节放疗后的尿毒症是前列腺癌的主要疗法。

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摘要

BACKGROUND AND PURPOSE: Urinary toxicity plays a major role in the quality of life (QOL) of patients treated with external beam radiotherapy as primary therapy for prostate cancer. In this study we report on: (1) Incidence of acute and late GU toxicity after intensity modulated radiotherapy (IMRT) for prostate cancer at Ghent University Hospital (GUH). (2) Time evolution of pre-IMRT and IMRT-induced acute and late GU toxicity. MATERIALS AND METHODS: At GUH, 260 patients with a follow-up of > or = 12 months were treated with IMRT for prostate cancer. The incidence and evolution of GU toxicity were recorded. RESULTS: Acute grades 3, 2 and 1 GU toxicity occurred in 8%, 42% and 42% of the patients, respectively. Late grades 3, 2 and 1 GU toxicity occurred in 3%, 19% and 40% of the patients, respectively. During therapy baseline grade 1 symptoms increased into grade 2 acute GU toxicity in 48%. After 1 and 2 years, 60% and 70% of the patients, respectively, had less GU symptoms when compared to the pre-treatment status. CONCLUSION: IMRT induces mild GU toxicity. There is an improvement in pre-IMRT obstructive miction disorders.
机译：背景与目的：尿毒症在作为前列腺癌主要治疗方法的体外放射线治疗患者的生活质量（QOL）中起着重要作用。在这项研究中，我们报告：（1）根特大学医院（GUH）对前列腺癌进行调强放疗（IMRT）后，急性和晚期GU毒性的发生率。 （2）IMRT前和IMRT诱发的GU急性和晚期毒性的时间演变。材料与方法：在GUH，对IMRT治疗的260例≥12个月的患者进行了前列腺癌治疗。记录了GU毒性的发生和演变。结果：分别有8％，42％和42％的患者发生了3、2和1 GU级急性毒性。晚期3、2和1 GU毒性分别发生在3％，19％和40％的患者中。在治疗期间，基线1级症状增加为2级急性GU毒性，占48％。与治疗前相比，在1年和2年后，分别有60％和70％的患者具有较少的GU症状。结论：IMRT诱导轻度GU毒性。 IMRT之前的阻塞性排尿障碍有所改善。

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