...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Cell cycle >Cellular microenvironment controls the nuclear architecture of breast epithelia through beta 1-integrin
【24h】

Cellular microenvironment controls the nuclear architecture of breast epithelia through beta 1-integrin

机译：细胞微环境通过β1-整合素控制乳腺上皮细胞的核结构

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Defects in nuclear architecture occur in a variety of diseases, however the fundamental mechanisms that control the internal structure of nuclei are poorly defined. Here we reveal that the cellular microenvironment has a profound influence on the global internal organization of nuclei in breast epithelia. A 3D microenvironment induces a prolonged but reversible form of cell cycle arrest that features many of the classical markers of cell senescence. This unique form of arrest is dependent on signaling from the external microenvironment through beta 1-integrins. It is concomitant with alterations in nuclear architecture that characterize the withdrawal from cell proliferation. Unexpectedly, following prolonged cell cycle arrest in 3D, the senescence-like state and associated reprogramming of nuclear architecture are freely reversible on altering the dimensionality of the cellular microenvironment. Breast epithelia can therefore maintain a proliferative plasticity that correlates with nuclear remodelling. However, the changes in nuclear architecture are cell lineage-specific and do not occur in fibroblasts, and moreover they are overcome in breast cancer cells.
机译：核结构的缺陷发生在多种疾病中，但是控制核内部结构的基本机制定义不清。在这里，我们揭示了细胞微环境对乳腺上皮细胞核的全球内部组织有深远的影响。 3D微环境会诱导延长但可逆的细胞周期停滞形式，其特征是许多细胞衰老的经典标记。逮捕的这种独特形式取决于通过β1整合素从外部微环境发出的信号。伴随着核结构改变的特征是细胞增殖停止。出乎意料的是，在3D中延长细胞周期停滞后，衰老样状态和相关的核结构重编程在改变细胞微环境的尺寸时可自由逆转。因此，乳房上皮细胞可以维持与核重塑相关的增殖可塑性。然而，核结构的改变是细胞谱系特异性的，在成纤维细胞中不会发生，而且在乳腺癌细胞中可以克服。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号