...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Neorectal hyposensitivity after neoadjuvant therapy for rectal cancer
【24h】

Neorectal hyposensitivity after neoadjuvant therapy for rectal cancer

机译：直肠癌新辅助治疗后的新直肠敏感性低下

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Background and purpose Preoperative radiotherapy for rectal cancer has a detrimental effect on long-term anorectal function and quality of life, additional to that observed after rectal resection. The exact physiological mechanisms for the excess impairment remain unknown. We aimed to investigate neorectal and anal sphincter properties in patients treated with neoadjuvant therapy (NT) prior to total mesorectal excision (TME). Material and methods Sixteen patients (NT+ patients) were examined by multimodal neorectal stimulation and standard anorectal physiological testing. Data were compared to the results of 23 patients, who underwent TME without NT (NT- patients). Results NT+ patients had elevated sensory thresholds to heat (median temperature, 60 vs. 55 C; p 0.01) and mechanical distension (median tension, 2513 vs. 1521 mmHg mm; p = 0.05) in the fasting state, and altered perception of the sensory response to heat (p = 0.01) and cold (p = 0.01) compared to NT- patients. No differences in the biomechanical properties of the neorectal wall were detected. Anal resting pressure was lower in NT+ patients compared to NT- patients (median pressure, 31 vs. 45 cm H2O; p = 0.05). Conclusions Pelvic radiotherapy causes neorectal hyposensitivity to mechanical and thermal stimuli in patients receiving NT prior to TME surgery for rectal cancer, possibly due to impaired afferent nerve function.
机译：背景与目的直肠癌的术前放疗对直肠切除术后的长期肛门直肠功能和生活质量有不利影响。过度损伤的确切生理机制仍然未知。我们旨在研究在全直肠系膜切除术（TME）之前接受新辅助治疗（NT）的患者的新直肠和肛门括约肌特性。材料和方法通过多模式新直肠刺激和标准的肛门直肠生理检查检查了16例患者（NT +患者）。将数据与23例接受NT的TME（NT患者）的结果进行比较。结果在空腹状态下，NT +患者的热感觉阈值（中度温度为60 vs. 55 C; p <0.01）和机械性扩张（中度张力为2513 vs. 1521 mmHg mm; p = 0.05）升高，并且对感觉的阈值有所改变与NT患者相比，对热（p = 0.01）和冷（p = 0.01）的感觉反应。未检测到新直肠壁的生物力学特性差异。与NT-患者相比，NT +患者的肛门静息压力更低（中位压力：31 vs. 45 cm H2O; p = 0.05）。结论骨盆放疗对直肠癌TME手术前接受NT的患者对机械和热刺激引起新直肠低敏性，可能是由于传入神经功能受损所致。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号