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首页> 外文期刊>Cell cycle >Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells.
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Elevated levels of thymidylate synthase linked to neoplastic transformation of mammalian cells.

机译：胸苷酸合酶水平升高与哺乳动物细胞的肿瘤转化有关。

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Thymidylate synthase (TS), an enzyme that is essential for DNA synthesis and repair has been identified as an important biomarker for colorectal and other human cancers. The elevated steady-state levels of TS found in many common human malignancies have been thought to represent a secondary event in tumor formation. However, it has recently been demonstrated that the deregulated levels of ectopic TS may also have a causal effect on tumorgenesis since overexpression of human TS transforms immortalized mammalian cells to a malignant phenotype. Since the levels of TS are regulated by E2F-1 and thus are linked to the cell cycle pathway, regulating TS activity may be an important factor for the control of cell cycle progression and for the development of therapeutic strategies and cancer prevention.
机译：胸苷酸合酶（TS）是DNA合成和修复必不可少的酶，已被认为是结直肠癌和其他人类癌症的重要生物标志物。在许多常见的人类恶性肿瘤中发现的TS稳态水平升高被认为代表了肿瘤形成中的继发事件。然而，最近已证明异位TS水平的失调也可能对肿瘤发生具有因果关系，因为人TS的过表达将永生的哺乳动物细胞转化为恶性表型。由于TS的水平受E2F-1调节，因此与细胞周期途径相关，因此调节TS活性可能是控制细胞周期进程，发展治疗策略和预防癌症的重要因素。

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