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首页> 外文期刊>Cell cycle >The chromatoid body of male germ cells: epigenetic control and miRNA pathway.
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The chromatoid body of male germ cells: epigenetic control and miRNA pathway.

机译：男性生殖细胞的染色体体：表观遗传控制和miRNA途径。

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摘要

Differentiation of germ cells is characterized by a remarkable degree of cellular restructuring and gene regulation that involves complex events of genomic and epigenetic reorganization. The pathways that govern miRNAs have been shown to play an important role in the male germ cell lineage. The chromatoid body is a finely filamentous, lobulated perinuclear granule located in the cytoplasm of male germ cells. The role of the chromatoid body in the mouse has remained elusive for longtime, although it was proposed to be involved in RNA storing and metabolism. Recent findings show that the chromatoid body is related to the RNA processing body (P-body) of somatic cells and that it seems to operate as an intracellular nerve-center of the microRNA pathway. The role of the chromatoid body underscores the importance of posttranscriptional gene regulation and of the microRNA pathway in the control of postmeiotic male germ cell differentiation.
机译：生殖细胞分化的特征是细胞重组和基因调控的程度很高，涉及基因组和表观遗传重组的复杂事件。已经证明，控制miRNA的途径在雄性生殖细胞谱系中起着重要作用。染色体样体是位于雄性生殖细胞胞质中的细丝状，小叶的核周颗粒。拟南芥体在小鼠中的作用长期以来仍难以捉摸，尽管有人提出它参与RNA的存储和代谢。最近的发现表明，类染色体体与体细胞的RNA处理体（P体）有关，并且它似乎作为microRNA途径的细胞内神经中心起作用。染色体体的作用强调了转录后基因调控和microRNA通路在减数分裂后雄性生殖细胞分化控制中的重要性。

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