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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Spinal cord ependymoma in children-Results of postoperative radiotherapy
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Spinal cord ependymoma in children-Results of postoperative radiotherapy

机译：儿童脊髓室管膜瘤-术后放疗的结果

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Purpose: A retrospective study was performed to evaluate the results of postoperative radiation therapy of spinal cord ependymoma in children. Methods and materials: Between 1984 and 2005, 28 children with spinal cord ependymoma were treated with radiotherapy, after surgery and in three cases after chemotherapy as well. Median age at diagnosis was 13.3 years (range from 4.7 to 16.2 years). Ependymoma myxopapillare was identified in 13, ependymoma in 12 and anaplastic ependymoma in 3 cases. Results: With a median follow-up of 8.7 years (range from 3 to 25 years) 22 patients were alive. The overall survival rate of 2, 5 and 10 years was 93%, 85% and 77% respectively, whereas progression free survival rate was 82%, 74% and 74% respectively. Patients with myxopapillary ependymoma had significantly better 5-year overall survival rate 100% than those with other histopathological types 60% (p = 0.016). There were 2 relapse incidences observed among 13 patients with myxopapillary ependymoma, both underwent repeated surgery and reirradiation. In the group of 20 patients with gross total resection the overall 5-year survival rate was 100% in comparison with 62.5% with partial surgery, but it did not achieve statistical significance. Conclusions: The histological type of ependymoma myxopapillary was a statistical significant favourable prognostic factor. The gross total resection with adjuvant radiotherapy allows obtaining a high total survival rate.
机译：目的：进行一项回顾性研究，以评估儿童脊髓室管膜瘤术后放射治疗的结果。方法和材料：1984年至2005年，对28例脊髓型室管膜瘤患儿进行了放疗，手术后以及3例化疗后的放疗。诊断时的中位年龄为13.3岁（范围为4.7至16.2岁）。黏膜室管膜膜囊炎13例，间质膜室膜瘤3例。结果：中位随访8.7年（3至25年），有22例患者存活。 2年，5年和10年的总生存率分别为93％，85％和77％，而无进展生存率分别为82％，74％和74％。黏液乳头状膜室膜瘤患者的5年总生存率明显好于其他组织病理学类型的患者60％（p = 0.016）。在13例患有黏液乳头状室囊膜瘤的患者中，有2例复发病例，均接受了反复手术和再次照射。在20例全切除的患者中，总的5年生存率是100％，而部分手术则为62.5％，但未达到统计学意义。结论：粘膜室管膜瘤的组织学类型是统计学上有利的预后因素。辅助放疗的总全切除术可实现较高的总生存率。

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