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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >In response to ESTRO 2012 strategy meeting: Vision for Radiation Oncology (published April 2012)
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In response to ESTRO 2012 strategy meeting: Vision for Radiation Oncology (published April 2012)

机译：为响应2012年ESTRO战略会议：放射肿瘤学的愿景（2012年4月发布）

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摘要

We thank Dahele and Senan for their interest in our prospective observational study TROG 99.05 [1].We will attempt to answer their questions as far as our data allow. It is difficult to assess in our data how to identify large tumors, using Dahele and Senan's cutpoint of a PTV of 700 cc or more, since PTV information was not collected. Assuming a GTV to PTV expansion of 1.5 cm, a sphere of volume 700 cc (diameter 11.0 cm) enclosing a concentric sphere with a radius 1.5 cm smaller (diameter 8.0 cm) has a volume of 270 cc. In our data 27 of the 509 patients (5.3%) had tumor volumes equal to or greater than 270 cc; and in 280 clinical stage III patients, this number was 22 (7.9%). There were 94 stage HI patients (33%) with tumors the same or larger than the upper quartile of volumes in all patients (110 cc). We will use this subset of 94 patients as those with large stage III tumors. For the following analyses, survival is measured from start of radiotherapy.
机译：感谢Dahele和​​Senan对我们的前瞻性观察性研究TROG 99.05 [1]感兴趣。我们将在数据允许的范围内尝试回答他们的问题。由于未收集PTV信息，因此难以使用Dahele和​​Senan的700 cc或更高PTV的临界点在我们的数据中评估如何识别大肿瘤。假设从GTV到PTV的膨胀为1.5 cm，则包围一个半径为1.5 cm（直径为8.0 cm）的同心球的体积为700 cc（直径为11.0 cm）的球体的体积为270 cc。在我们的数据中，509名患者中有27名（5.3％）的肿瘤体积等于或大于270 cc。在280例临床III期患者中，这一数字为22（7.9％）。在所有患者（110 cc）中，有94例HI分期患者（33％）的肿瘤大小等于或大于上四分位数。我们将把这94名患者的子集用作患有III期大肿瘤的患者。对于以下分析，从放疗开始就测量存活率。

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