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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Progressive resistance training rebuilds lean body mass in head and neck cancer patients after radiotherapy - Results from the randomized DAHANCA 25B trial
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Progressive resistance training rebuilds lean body mass in head and neck cancer patients after radiotherapy - Results from the randomized DAHANCA 25B trial

机译：渐进式阻力训练可在放疗后重建头颈癌患者的瘦体重-DAHANCA 25B随机试验的结果

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Purpose The critical weight loss observed in head and neck squamous cell carcinoma (HNSCC) patients following radiotherapy is mainly due to loss of lean body mass. This is associated with decreases in muscle strength, functional performance and Quality of Life (QoL). The present study investigated the effect of progressive resistance training (PRT) on lean body mass, muscle strength and functional performance in HNSCC patients following radiotherapy. Patients and methods Following radiotherapy HNSCC patients were randomized into two groups: Early Exercise (EE, n = 20) initiated 12 weeks of PRT followed by 12 weeks of self-chosen physical activity. Delayed Exercise (DE, n = 21) initiated 12 weeks of self-chosen physical activity followed by 12 weeks of PRT. Lean body mass, muscle strength, functional performance and QoL were evaluated at baseline and after week 12 and 24. Results In the first 12 weeks lean body mass increased by 4.3% in EE after PRT and in the last 12 weeks by 4.2% in DE after PRT. These increases were significantly larger than the changes after self-chosen physical activity (p ≤ 0.005). Regardless of PRT start-up time, the odds ratio of increasing lean body mass by more than 4% after PRT was 6.26 (p < 0.05). PRT significantly increased muscle strength, whereas functional performance increased significantly more than after self-chosen physical activity only after delayed onset of PRT. Overall QoL improved significantly more in EE than DE from baseline to week 12. Conclusion PRT effectively increased lean body mass and muscle strength in HNSCC patients following radiotherapy, irrespectively of early or delayed start-up.
机译：目的放疗后在头颈部鳞状细胞癌（HNSCC）患者中观察到的关键体重减轻主要是由于瘦体重的损失。这与肌肉力量，功能表现和生活质量（QoL）下降有关。本研究调查了放疗后进行性抵抗训练（PRT）对HNSCC患者的瘦体重，肌肉力量和功能表现的影响。患者和方法放疗后，HNSCC患者被随机分为两组：早期锻炼（EE，n = 20）开始12周的PRT，然后进行12周的自选体力活动。延迟运动（DE，n = 21）开始了12周的自我选择的体育锻炼，随后是12周的PRT。在基线以及第12周和第24周后评估瘦体重，肌肉力量，功能表现和QoL。结果在PRT后的EE中，前12周的瘦体重增加了4.3％，而在DE的最后12周，瘦体重增加了4.2％在PRT之后。这些增加显着大于自我选择的体育活动后的变化（p≤0.005）。不论PRT启动时间如何，PRT后瘦体重增加4％以上的几率是6.26（p <0.05）。 PRT显着增加了肌肉力量，而仅在PRT延迟发作后，功能性能显着高于自我选择的身体活动。从基线到第12周，EE的总体QoL改善显着大于DE。结论PRT有效地提高了放疗后HNSCC患者的瘦体重和肌肉力量，无论是早期启动还是延迟启动。

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