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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Plan of the day selection for online image-guided adaptive post-prostatectomy radiotherapy
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Plan of the day selection for online image-guided adaptive post-prostatectomy radiotherapy

机译：在线图像引导的适应性前列腺切除术后放疗的每日选择计划

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Purpose To compare the cone-beam CT (CBCT) soft tissue localization disparity between radiation oncologists (RO) and radiation therapy technologists (RTT) in a novel online protocol of image-guided adaptive radiotherapy to the postoperative prostate bed. Method Using the planning CT and pre-treatment CBCTs from the first week of radiotherapy, four adaptive plans of different sizes were derived for each of eight post-prostatectomy patients. Four ROs collectively defined the reference answer, i.e. the plan of the day and isocentre correction for 40 CBCTs taken in weeks 2-6 of treatment for each patient. RTTs were randomly assigned five of these CBCTs; and asked to record their plan of the day selection and isocentre correction. RTT selection and reference answers were compared. The distance between the RTT selection and the reference answer was calculated. Results A total of 33 RTTs took part in this study. The average difference in CTV volume (reference answer-RTT selection) was 1.32 cm3 (SD 29 cm3) overall. The average difference between reference answer and RTT isocentre coordinates was SI 1 mm (SD 4.8 mm), LR 1.1 mm (SD 4.0 mm) and AP -0.2 mm (SD 3.9 mm). Distance of superior 8 mm, inferior 6 mm, left 4 mm, right 2 mm, anterior 6 mm and posterior 6 mm covered 100% of the CTV in 90% of fractions. Conclusion The difference between RTT and RO selection of adaptive volumes is small and can be accounted for in a clinically acceptable CTV to PTV margin. Adaptive post-prostatectomy radiotherapy is feasible, in the setting of an academic center although at the moment, we have insufficient evidence to suggest that margins can yet be reduced with IGART with the current protocol.
机译：目的在影像引导适应性放射治疗的新型在线协议中，比较放射肿瘤学家（RO）和放射治疗技术人员（RTT）之间的锥束CT（CBCT）软组织定位差异到术后前列腺床。方法使用放射治疗第一周的CT计划和CBCT预处理，为8位前列腺切除术后患者分别制定了4种不同大小的适应性计划。四个RO共同定义了参考答案，即每位患者在治疗的第2-6周采取的每日计划和40个CBCT的等中心点校正。将RTT随机分配给这些CBCT中的五个;并要求记录他们的当日选择和等中心线校正计划。比较了RTT选择和参考答案。计算了RTT选择和参考答案之间的距离。结果共有33个RTT参与了这项研究。总的来说，CTV音量（参考答案-RTT选择）的平均差异为1.32 cm3（SD 29 cm3）。参考答案和RTT等中心坐标之间的平均差为SI 1毫米（SD 4.8毫米），LR 1.1毫米（SD 4.0毫米）和AP -0.2毫米（SD 3.9毫米）。上8毫米，下6毫米，左4毫米，右2毫米，前6毫米和后6毫米的距离以90％的比例覆盖了CTV的100％。结论RTT和RO选择自适应量之间的差异很小，可以在临床上接受的CTV到PTV的差异中得到解释。在一个学术中心内，尽管目前尚无足够的证据表明采用目前的方案使用IGART仍可降低利润率，但在学术中心内进行适应性前列腺切除术后放疗是可行的。

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