Blood and lymphatic microvessel damage in irradiated human skin: The role of TGF-beta, endoglin and macrophages

Russell Nicola S.; Floot Ben; van Werkhoven Erik; Schriemer Mitchel; de Jong-Korlaar Regina; Woerdeman Leonie A. E.; Stewart Fiona A.; Scharpfenecker Marion

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Blood and lymphatic microvessel damage in irradiated human skin: The role of TGF-beta, endoglin and macrophages

机译：辐射的人类皮肤中的血液和淋巴微血管损伤：TGF-β，内皮糖蛋白和巨噬细胞的作用

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Background and purpose: Microvascular damage is an important component of late radiation-induced morbidity. In our pre-clinical models, we demonstrated that repair of vessel injury is dependent on proper endoglin-mediated transforming growth factor-beta (TGF-beta) signalling and that it can be affected by infiltrating macrophages. We now wanted to extend these findings in irradiated patients, using skin as a model system, and assess whether bisphosphonates could modulate the response.

机译：背景与目的：微血管损伤是晚期辐射诱发发病的重要组成部分。在我们的临床前模型中，我们证明了血管损伤的修复取决于适当的内皮糖蛋白介导的转化生长因子-β（TGF-β）信号传导，并且它可能会受到巨噬细胞浸润的影响。现在，我们希望使用皮肤作为模型系统，在接受放射治疗的患者中扩展这些发现，并评估双膦酸盐是否可以调节反应。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2015年第3期|共7页
作者
Russell Nicola S.; Floot Ben; van Werkhoven Erik; Schriemer Mitchel; de Jong-Korlaar Regina; Woerdeman Leonie A. E.; Stewart Fiona A.; Scharpfenecker Marion;
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正文语种 eng
中图分类肿瘤学;
关键词
Telangiectasia; Vascular damage; Lymphoedema; Bisphosphonates; Endoglin; TGF-beta;

机译：毛细血管扩张;血管损伤;淋巴水肿;双膦酸盐;恩多克林;TGF-β;

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1. 休克淋巴液对大鼠肺微血管内皮细胞的损伤作用 [J] . 牛春雨, 赵自刚, 李继承, 分子细胞生物学报（英文版） . 2007,第002期
2. Blood and lymphatic microvessel damage in irradiated human skin: The role of TGF-beta, endoglin and macrophages [J] . Russell Nicola S., Floot Ben, van Werkhoven Erik, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2015,第3期

机译：辐射的人类皮肤中的血液和淋巴微血管损伤：TGF-β，内皮糖蛋白和巨噬细胞的作用
3. Blood microvessel density, lymphatic microvessel density and lymphatic invasion in predicting melanoma metastases: Systematic review and meta-analysis [J] . PastushenkoI., VermeulenP.B., CarapetoF.J., British Journal of Dermatology . 2014,第1期

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4. Mouse skin-derived precursors alleviates ultraviolet B irradiation damage via early activation of TGF-beta/Smad pathway by thrombospondin1 [J] . Li Yiming, Xiong Lidan, Tang Jie, Cell cycle . 2020,第4期

机译：小鼠皮肤衍生的前体通过血压出素1通过早期激活TGF-Beta / Smad途径来减轻紫外线B辐照损伤
5. Modern stereological methods for studying blood and lymphatic microvessels [C] . R.A. Krasnoperov World congress on medical physics and biomedical engineering;International congress of the IUPESM . 2011

机译：研究血液和淋巴微血管的现代立体学方法
6. I. Differential gene expression in human peripheral blood monocytes and alveolar macrophages. II. Macrophage colony-stimulating factor is important in the development of pulmonary fibrosis. [D] . Opalek, Judy Marcus. 2004

机译：I.人外周血单核细胞和肺泡巨噬细胞中的差异基因表达。二。巨噬细胞集落刺激因子在肺纤维化的发展中很重要。
7. Dilated Blood and Lymphatic Microvessels Angiogenesis Increased Macrophages and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue [O] . Sara AL-Ghadban, Walter Cromer, Marisol Allen, 2019

机译：血脂大腿皮肤和脂肪组织中的血液和淋巴微血管扩张血管生成巨噬细胞增加和脂肪细胞肥大
8. Dilated Blood and Lymphatic Microvessels, Angiogenesis, Increased Macrophages, and Adipocyte Hypertrophy in Lipedema Thigh Skin and Fat Tissue [O] . Sara AL-Ghadban, Walter Cromer, Marisol Allen, 2019

机译：在Lipedema Thigh皮肤和脂肪组织中扩张血液和淋巴微血管，血管生成，增加，巨噬细胞和脂肪细胞肥大
9. Effects of Blood Flow on Skin Heating Induced by Millimeter Wave Irradiation in Humans. [R] . Walters, T. J., Ryan, K. L., Nelson, D. A., 2004

机译：血流对人体毫米波辐射诱发皮肤加热的影响。

Blood and lymphatic microvessel damage in irradiated human skin: The role of TGF-beta, endoglin and macrophages

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