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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Accelerated partial irradiation for breast cancer: Systematic review and meta-analysis of 8653 women in eight randomized trials
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Accelerated partial irradiation for breast cancer: Systematic review and meta-analysis of 8653 women in eight randomized trials

机译：加速乳腺癌局部照射：在八项随机试验中对8653名妇女的系统评价和荟萃分析

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Background and purpose: Accelerated partial breast irradiation (APBI) is the strategy that allows adjuvant treatment delivery in a shorter period of time in smaller volumes. This study was undertaken to assess the effectiveness and outcomes of APBI in breast cancer compared with whole-breast irradiation (WBI). Material and methods: Systematic review and meta-analysis of randomized controlled trials of WBI versus APBI. Two authors independently selected and assessed the studies regarding eligibility criteria. Results: Eight studies were selected. A total of 8653 patients were randomly assigned for WBI versus APBI. Six studies reported local recurrence outcomes. Two studies were matched in 5 years and only one study for different time of follow-up. Meta-analysis of two trials assessing 1407 participants showed significant difference in the WBI versus APBI group regarding the 5-year local recurrence rate (HR = 4.54, 95% CI: 1.78-11.61, p = 0.002). Significant difference in favor of WBI for different follow-up times was also found. No differences in nodal recurrence, systemic recurrence, overall survival and mortality rates were observed. Conclusions: APBI is associated with higher local recurrence compared to WBI without compromising other clinical outcomes. (C) 2014 Elsevier Ireland Ltd. All rights reserved.
机译：背景与目的：加速局部乳房照射（APBI）是一种可以在较短时间内以较小体积进行辅助治疗的策略。这项研究旨在评估APBI与全乳照射（WBI）相比在乳腺癌中的有效性和结果。材料和方法：WBI与APBI随机对照试验的系统评价和荟萃分析。两位作者独立选择并评估了有关资格标准的研究。结果：选择了八项研究。共有8653名患者被随机分配为WBI与APBI。六项研究报告了局部复发结局。在5年内对两项研究进行了匹配，只有一项研究在不同的随访时间进行了匹配。两项评估1407名参与者的试验的荟萃分析显示，WBI组和APBI组在5年局部复发率方面有显着差异（HR = 4.54，95％CI：1.78-11.61，p = 0.002）。还发现在不同的随访时间中对WBI的支持存在显着差异。淋巴结复发，全身性复发，总生存率和死亡率均无差异。结论：与WBI相比，APBI与更高的局部复发率相关联，而不会影响其他临床结果。 （C）2014 Elsevier Ireland Ltd.保留所有权利。

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