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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Interaction of EGFR with the tumour microenvironment: Implications for radiation treatment
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Interaction of EGFR with the tumour microenvironment: Implications for radiation treatment

机译：EGFR与肿瘤微环境的相互作用：放射治疗的意义

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Treatment failure through radioresistance of tumours is associated with activation of the epidermal growth factor receptor (EGFR). Tumour cell proliferation, DNA-repair, hypoxia and metastases-formation are four mechanisms in which EGFR signalling has an important role. In clinical trials, a correlation has been demonstrated between high EGFR expression in tumours and poor outcome after radiotherapy. Inhibition of EGFR signalling pathways improves the effectiveness of radiotherapy of head and neck cancers by overcoming these main mechanisms of radioresistance. The fact that only a minority of the patients respond to EGFR inhibitors reflects the complexity of interactions between EGFR-dependent signalling pathways and the tumour microenvironment. Furthermore, many components of the microenvironment are potential targets for therapeutic interventions. Characterisation of the interaction of EGFR signalling and the tumour microenvironment is therefore necessary to improve the effectiveness of combined modality treatment with radiotherapy and targeted agents. Here, the current status of knowledge is reviewed and directions for future research are discussed.
机译：通过肿瘤的放射抗性导致的治疗失败与表皮生长因子受体（EGFR）的激活有关。肿瘤细胞增殖，DNA修复，缺氧和转移形成是EGFR信号传导具有重要作用的四个机制。在临床试验中，已证明肿瘤中EGFR高表达与放疗后不良结局之间存在相关性。通过克服这些主要的抗放射性机制，抑制EGFR信号通路可提高头颈癌放射疗法的有效性。仅有少数患者对EGFR抑制剂有反应这一事实反映了EGFR依赖性信号通路与肿瘤微环境之间相互作用的复杂性。此外，微环境的许多组成部分是治疗干预的潜在目标。因此，表征EGFR信号转导和肿瘤微环境的相互作用对于提高放射治疗和靶向药物联合治疗的有效性是必要的。在这里，对知识的现状进行了回顾，并讨论了未来研究的方向。

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