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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Implementation and initial clinical experience of offline PET/CT-based verification of scanned carbon ion treatment
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Implementation and initial clinical experience of offline PET/CT-based verification of scanned carbon ion treatment

机译：基于离线PET / CT的扫描碳离子治疗验证的实施和初步临床经验

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Background and purpose We report on the implementation of offline PET/CT-based treatment verification at the Heidelberg Ion Beam Therapy Centre (HIT) and present first clinical cases for post-activation measurements after scanned carbon ion irradiation. Key ingredient of this in-vivo treatment verification is the comparison of irradiation-induced patient activation measured by a PET scanner with a prediction simulated by means of Monte Carlo techniques. Material and methods At HIT, a commercial full-ring PET/CT scanner has been installed in close vicinity to the treatment rooms. After selected irradiation fractions, the patient either walks to the scanner for acquisition of the activation data or is transported using a shuttle system. The expected activity distribution is obtained from the production of β+- active isotopes simulated by the FLUKA code on the basis of the patient-specific treatment plan, post-processed considering the time course of the respective treatment fraction, the estimated biological washout of the induced activity and a simplified model of the imaging process. Results We present four patients with different indications of head, headeck, liver and pelvic tumours. A clear correlation between the measured PET signal and the simulated activity pattern is observed for all patients, thus supporting a proper treatment delivery. In the case of a pelvic tumour patient it was possible to detect minor treatment delivery inaccuracies. Conclusions The initial clinical experience proves the feasibility of the implemented strategy for offline confirmation of scanned carbon ion irradiation and therefore constitutes a first step towards a comprehensive PET/CT-based treatment verification in the clinical routine at HIT.
机译：背景与目的我们报告了海德堡离子束治疗中心（HIT）实施基于离线PET / CT的治疗验证的情况，并介绍了扫描碳离子辐照后进行激活后测量的首例临床病例。体内治疗验证的关键因素是将PET扫描仪测量的辐射诱导的患者激活与通过蒙特卡洛技术模拟的预测进行比较。材料和方法在HIT，在治疗室附近安装了商用全环PET / CT扫描仪。在选定的辐射分数之后，患者要么走到扫描仪以获取激活数据，要么使用穿梭系统进行转运。预期的活性分布是根据患者特定的治疗计划，通过FLUKA代码模拟的β+-活性同位素的产生而获得的，经过后处理时考虑了各个治疗分数的时程，估计的生物洗脱能力。诱导的活动和成像过程的简化模型。结果我们介绍了四位患者的头，头/颈部，肝和盆腔肿瘤的适应症。对于所有患者，都可以观察到所测量的PET信号与模拟活动模式之间的明确关联，从而支持正确的治疗交付。对于骨盆肿瘤患者，可能会发现轻微的治疗交付不准确之处。结论初步的临床经验证明了所实施策略可以离线确认扫描的碳离子辐射的可行性，因此构成了HIT临床程序中全面基于PET / CT的治疗验证的第一步。

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