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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Target volume for postoperative radiotherapy in non-small cell lung cancer: Results from a prospective trial
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Target volume for postoperative radiotherapy in non-small cell lung cancer: Results from a prospective trial

机译：非小细胞肺癌术后放疗目标体积：一项前瞻性试验结果

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Background and purpose A previous prospective trial reported that three-dimensional conformal postoperative radiotherapy (PORT) for pN2 NSCLC patients using a limited clinical target volume (CTV) had a late morbidity rate and pulmonary function that did not differ from those observed in pN1 patients treated with surgery without PORT. The aim of this study was to assess locoregional control and localization of failure in patients treated with PORT. Materials and methods The pattern of locoregional failure was evaluated retrospectively in 151 of 171 patients included in the PORT arm. The CTV included the involved lymph node stations and those with a risk of invasion >10%. Competing risk analysis was used to assess the incidence of locoregional failure and its location outside the CTV. Results Overall survival at 5 years was 27.1% with a median follow-up of 67 months for 40 living patients. The 5-year cumulative incidence of locoregional failure was 19.4% (95% CI: 18.2-20.5%) including a failure rate of 2% (95% CI: 0-17%) in locations outside or at the border of the CTV. Conclusions The use of limited CTV was associated with acceptable risk of geographic miss. Overall locoregional control was similar to that reported by other studies using PORT for pN2 patients.
机译：背景和目的先前的一项前瞻性试验报道，使用有限的临床目标量（CTV）对pN2 NSCLC患者进行三维适形术后放射治疗（PORT）的晚期发病率和肺功能与在治疗的pN1患者中观察到的无差异没有PORT的手术。本研究的目的是评估接受PORT治疗的患者的局部控制和失败的定位。材料和方法回顾性分析了PORT组中171例患者中的151例的局部衰竭类型。 CTV包括受累淋巴结站和那些有浸润风险> 10％的淋巴结站。竞争风险分析用于评估局部衰竭的发生率及其在CTV之外的位置。结果40名在世患者的5年总生存率为27.1％，中位随访67个月。局部区域故障的5年累积发生率为19.4％（95％CI：18.2-20.5％），其中CTV外部或边界的故障率为2％（95％CI：0-17％）。结论使用有限的CTV与可接受的地理缺失风险相关。总体局部控制与pN2患者使用PORT的其他研究报告的相似。

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