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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >The role of overall treatment time in the outcome of radiotherapy of prostate cancer: an analysis of biochemical failure in 4839 men treated between 1987 and 1995.
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The role of overall treatment time in the outcome of radiotherapy of prostate cancer: an analysis of biochemical failure in 4839 men treated between 1987 and 1995.

机译：总体治疗时间在前列腺癌放射治疗结果中的作用：对1987年至1995年间接受治疗的4839名男性的生化衰竭的分析。

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PURPOSE: Assess the importance of overall time (OT) and dose for biochemical failure (BF) after external-beam radiotherapy of prostate cancer in a retrospective analysis of a nine-institution database with 4839 patients. PATIENTS AND METHODS: Relevant baseline factors (T stage, Gleason score, initial PSA) were available for 4338 men. Cox models were used to estimate the effects of dose and OT corrected for baseline factors, treatment year, institution and interactions, and differences in post-treatment PSA-measurement intervals. After exclusion of very short and long intervals, patient numbers were 1445 events/3426 at risk (endpoint all BFs), and 1177 events/3354 at risk (endpoint exclusion of BFs that were likely distant failures). Separate analyses were carried out by risk group for men who received <70 Gy and > or = 70 Gy. RESULTS: Neither dose nor OT was significant when the analysis was restricted to doses <70 Gy, while for patients treated to 70 Gy or higher there were significant influences of both dose and OT on outcome in low- and intermediate-risk patients. These effects were quantified as a relative increase after 5 years followup of 6% in BFs for a 1-week increase in OT, a relative decrease of 15% in BFs for a 6-Gy increase in dose, and a dose equivalent of proliferation of 0.24 Gy/day. As the dose per fraction was nearly constant, the data contain no information on the alpha/beta ratio. CONCLUSION: The results show that OT and dose are significant determinants of outcome of radiotherapy in low- and intermediate-risk patients treated to 70 Gy or higher, and suggest that meaningful improvements in outcome may be targeted by modest increases in total dose and decreases in OT.
机译：目的：在一项回顾性分析9所拥有4839名患者的数据库中，评估前列腺癌的体外束放射治疗后总时间（OT）和剂量对生化衰竭（BF）的重要性。患者和方法：4338名男性可获得相关的基线因素（T分期，格里森评分，初始PSA）。使用Cox模型评估针对基线因素，治疗年份，机构和相互作用以及治疗后PSA测量间隔的差异校正的剂量和OT的影响。在排除非常短和很长的间隔后，患者人数为1445事件/ 3426有风险（终点为所有BF），有1177事件/ 3354有风险（终点排除可能为远距离衰竭的BF）。风险组针对接受<70 Gy和>或= 70 Gy的男性进行了单独的分析。结果：当分析仅限于小于70 Gy的剂量时，剂量或OT均无统计学意义，而对于70 Gy或更高剂量的患者，低剂量和中度风险患者的剂量和OT均对预后产生重大影响。这些效应被量化为OT升高1周后BFs 6％随访5年后的相对增加，剂量增加6-Gy时BFs相对降低15％，以及与0.24 Gy /天。由于每部分的剂量几乎恒定，因此数据不包含有关α/β比的信息。结论：结果表明，在接受70 Gy或更高治疗的低危和中危患者中，OT和剂量是放疗结果的重要决定因素，并表明总剂量的适度增加和放疗剂量的降低可能是有意义的预后改善目标。加时。

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