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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy.
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Development of a patient-reported questionnaire for collecting toxicity data following prostate brachytherapy.

机译：病人报告调查表的开发，用于收集前列腺近距离放射治疗后的毒性数据。

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PURPOSE: To improve a questionnaire used to collect patient-reported outcomes from patients with early stage prostate cancer treated with brachytherapy. A secondary aim was to adapt the Late Effects of Normal Tissue (LENT) subjective toxicity questionnaire for use to collect Common Terminology Criteria for Adverse Events (CTCAE) data, the current preferred platform for assessing radiation toxicity. MATERIALS AND METHODS: Three hundred and seventy-seven patients were treated with permanent iodine-125 seed implant brachytherapy for early prostate cancer. Toxicity data were collected before and at nine time points post-treatment (0-36 months). Compliance rates for patients completing individual items and item-subsection correlation coefficients were calculated. A factor analysis was carried out to analyse responses to the questionnaire and identify less informative questions, which could be removed. Cronbach's alpha coefficient was used to measure reliability. RESULTS: Two thousand one hundred and eighty-eight questionnaires were analysed. There was poor compliance for questions specifically relating to operations and bowel medication. We found that the division of the questionnaire into subsections based on anatomical site was reasonable and that certain items could be safely removed. The high mean value for Cronbach's alpha across all questionnaires (0.752; 95% CI: 0.726-0.779) indicated that the questionnaire was reliable. Fifteen of the 44 questions were removed from the original questionnaires. Questions on urinary incontinence severity, management of urinary and bowel incontinence, effects of reduced flow of urine and the effects of symptoms on activity of daily living and change in sexual function were required to adapt the LENT subjective questionnaire for use to collect CTCAE data. CONCLUSIONS: A questionnaire, validated over 6 years to collect LENT subjective data were adapted and is a reliable approach for collecting CTCAE data after prostate brachytherapy.
机译：目的：改进一项问卷调查，以收集接受近距离放射治疗的早期前列腺癌患者的患者报告结果。第二个目的是调整正常组织的后期效应（LENT）主观毒性调查表，以收集不良事件的通用术语标准（CTCAE）数据，该数据是目前评估放射毒性的首选平台。材料与方法：377例患者接受了永久性碘125粒子植入物近距离放射治疗，以治疗早期前列腺癌。在治疗前和治疗后九个时间点（0-36个月）收集毒性数据。计算完成单个项目的患者的依从率和项目-分段相关系数。进行了因素分析，以分析对问卷的答复并确定信息量较小的问题，可以将其删除。克朗巴赫（Cronbach）α系数用于衡量可靠性。结果：分析了288个问卷。对于与手术和肠道药物有关的问题，依从性差。我们发现，根据解剖部位将调查表划分为多个小节是合理的，并且可以安全地删除某些项目。在所有问卷中，克伦巴赫（Cronbach's）α均值较高（0.752; 95％CI：0.726-0.779），表明该问卷是可靠的。从原始问卷中删除了44个问题中的15个。为了适应LENT主观问卷以收集CTCAE数据，需要有关尿失禁的严重程度，尿失禁和肠道失禁的管理，尿流减少的影响以及症状对日常生活活动和性功能改变的影响。结论：对问卷进行了修改，该问卷经过6年的验证，可以收集LENT主观数据，是在前列腺癌近距离放射治疗之后收集CTCAE数据的可靠方法。

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