Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data.

Selo N; Bolling T; Ernst I; Pape H; Martini C; Rube C; Timmermann B; Fischedick K; Kortmann RD; Gerss J; Koch R; Willich N

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Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data.

机译：690名儿童和青少年放射治疗的急性毒性特征：RiSK数据。

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BACKGROUND AND PURPOSE: The "Registry for the evaluation of side effects after radiation in childhood and adolescence" (risk) was introduced to characterize adverse effects of radiotherapy in childhood and adolescence prospectively. The aim of this analysis was to characterize the pattern of acute side effects. MATERIALS AND METHODS: Since 2001, patients receiving radiotherapy in one of the German pediatric therapy trials have been registered in RiSK with detailed information regarding radiation doses to organs at risk and characterization of acute toxicities. RESULTS: From 2001 to May 2009, 690 patients have been characterized for acute toxicity in primary therapy. Acute toxicity >/= grade 1 was observed in 506 patients. In patients irradiated in their lung and liver, patients with grade 1 or 2 acute toxicities showed higher organ volumes exposed to radiation doses <20 Gray (Gy) compared to patients without toxicities. For the salivary glands, there was a positive correlation between the acute toxicity grade and the maximum radiation dose to the organ; the lower GI tract showed a similar trend. The impact of different chemotherapy regimens on these acute side effects remains unclear. Age did not have any impact on side effects. CONCLUSION: This analysis gives a comprehensive overview of the acute toxicities of radiotherapy in children and adolescents. With prolongation of follow-up, detailed analyses regarding late toxicities will be possible with the characterization of dose-volume-effect relationships.

机译：背景与目的：引入“评估儿童和青少年放射后副作用的注册”（风险），以表征放射治疗对儿童和青少年的不良影响。该分析的目的是表征急性副作用的模式。材料与方法：自2001年以来，在德国的一项儿科治疗试验中接受放射治疗的患者已在RiSK进行了注册，其中包括对有风险的器官的放射剂量和急性毒性特征的详细信息。结果：从2001年到2009年5月，已有690例患者在主要治疗中表现出急性毒性的特征。在506名患者中观察到≥1的急性毒性。与没有毒性的患者相比，在接受肺和肝照射的患者中，具有1或2级急性毒性的患者暴露于<20 Gray（Gy）辐射剂量下，器官体积更大。对于唾液腺，急性毒性等级与对器官的最大辐射剂量之间存在正相关关系。下消化道也有类似的趋势。尚不清楚不同化疗方案对这些急性副作用的影响。年龄对副作用没有任何影响。结论：该分析全面概述了放射线治疗儿童和青少年的急性毒性。随着随访时间的延长，随着剂量-体积-效应关系的表征，有关后期毒性的详细分析将成为可能。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2010年第1期|共8页
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Selo N; Bolling T; Ernst I; Pape H; Martini C; Rube C; Timmermann B; Fischedick K; Kortmann RD; Gerss J; Koch R; Willich N;
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1. Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data. [J] . Selo N, Bolling T, Ernst I, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2010,第1期

机译：690名儿童和青少年放射治疗的急性毒性特征：RiSK数据。
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Acute toxicity profile of radiotherapy in 690 children and adolescents: RiSK data.

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