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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging.
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Differentiation between hypoxic and non-hypoxic experimental tumors by dynamic contrast-enhanced magnetic resonance imaging.

机译：通过动态对比增强磁共振成像来区分低氧和非低氧实验性肿瘤。

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BACKGROUND AND PURPOSE: Dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) has been suggested to be a useful method for detecting tumor hypoxia. In this study, we investigated whether DCE-MRI can differentiate between hypoxic and non-hypoxic experimental tumors. MATERIALS AND METHODS: Three tumor models with hypoxic tissue and three tumor models without hypoxic tissue were subjected to DCE-MRI. Parametric images of K(trans) (the volume transfer constant of Gd-DTPA) and v(e) (the fractional distribution volume of Gd-DTPA) were produced by pharmacokinetic analysis of the DCE-MRI series. Tumor oxygenation status was assessed by using a radiobiological assay and a pimonidazole-based immunohistochemical assay. Tumor response to fractionated irradiation (six fractions of 2Gy in 60h) was measured in vitro by using a clonogenic assay. RESULTS: Tumors with hypoxic regions were more resistant to radiation treatment than were tumors without hypoxia. K(trans) was significantly higher for radiation sensitive tumors without hypoxia than for radiation resistant tumors with hypoxic regions, whereas v(e) did not differ significantly between non-hypoxic and hypoxic tumors. CONCLUSION: This study supports the clinical attempts to establish DCE-MRI as a noninvasive method for providing useful biomarkers for personalized radiation therapy.
机译：背景与目的：动态对比度增强磁共振成像（DCE-MRI）被认为是检测肿瘤缺氧的一种有用方法。在这项研究中，我们调查了DCE-MRI是否可以区分低氧和非低氧实验性肿瘤。材料与方法：对三种具有低氧组织的肿瘤模型和三种无低氧组织的肿瘤模型进行DCE-MRI检查。通过DCE-MRI系列的药代动力学分析得出K（反式）（Gd-DTPA的体积转移常数）和v（e）（Gd-DTPA的分数分布体积）的参数图像。肿瘤的氧合状态通过放射生物学分析和基于吡莫硝唑的免疫组织化学分析进行评估。通过使用克隆形成试验在体外测量了对分级照射的肿瘤反应（在60h内有6个2Gy的级分）。结果：缺氧区域的肿瘤比无缺氧的肿瘤对放射治疗的抵抗力更高。没有缺氧的辐射敏感性肿瘤的K（trans）显着高于有缺氧区域的抗辐射肿瘤的K（trans），而无缺氧和低氧的肿瘤之间的v（e）没有显着差异。结论：本研究支持建立DCE-MRI作为无创方法为个性化放射治疗提供有用的生物标志物的临床尝试。

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