...
首页> 外文期刊>Cell cycle >Kinases involved in Rec8 phosphorylation revealed.
【24h】

Kinases involved in Rec8 phosphorylation revealed.

机译:显示参与Rec8磷酸化的激酶。

获取原文
获取原文并翻译 | 示例
           

摘要

During meiosis, the number of chromosomes is reduced by half in two nuclear divisions following only a single DNA replication in premeiotic S phase. Successful segregation of chromosomes during this process requires stepwise removal of cohesion between sister chromatids, which is mediated by cohesin complex. Cohesion between chromosome arms, which in meiosis is essential for holding homologous chromosomes together after chi-asmata formation, is removed during meiosis I, whereas centromeric cohesion, mediating connection between sister chromatids, has to be maintained until meiosis II. It was demonstrated that the removal of cohesin during meiosis requires proteolytic cleavage of its a-kleisin subunit Rec8 by Separase.
机译:在减数分裂过程中,仅在减数分裂前S期进行一次DNA复制后,两个核分裂中的染色体数目就会减少一半。在此过程中,成功的染色体分离需要逐步消除姐妹染色单体之间的凝聚力,这是由凝聚素复合物介导的。在减数分裂I期间,染色体臂之间的凝聚力(在减数分裂中对于将同源染色体保持在一起后必不可少)是必需的,但在减数分裂I期间必须去除,而介导的姊妹染色单体之间的连接的着丝粒凝聚力必须保持到减数分裂II为止。结果表明,减数分裂过程中黏附素的去除需要通过Separase对其a-kleisin亚基Rec8进行蛋白水解切割。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号