Circadian rhythms and cancer.

Koeffler HP

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Circadian rhythms and cancer.

机译：昼夜节律和癌症。

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The circadian clock is an endogenous time keeping system shared by most organisms. In mammals, a master pacemaker in the hypothalamus orchestrates temporal alignment of behavior and physiology by transmitting daily signals to multiple clocks in peripheral tissues. Disruption of this communication has a profound affect on human health and has been linked to diverse pathogenic conditions, including cancer. At the center of the molecular circadian machinery is a set of clock genes, generating rhythmic oscillations on a cellular level. In the past several years, research from different fields has revealed the complexity and ubiquitous nature of circadian regulation, uncovering intriguing associations between clock components and cellular pathways implicated in tumorigenesis. In this review, we discuss the emerging role of circadian genes in hematological and hormone-related malignances. These new insights suggest that manipulating circadian biology as a way to fight cancer, as well as, other life threatening diseases is within the realm of possibility.

机译：昼夜节律时钟是大多数生物共享的内源性计时系统。在哺乳动物中，下丘脑的起搏器通过将日常信号传输到周围组织的多个时钟来协调行为和生理的时间对准。中断这种交流会对人类健康产生深远影响，并与包括癌症在内的多种致病条件有关。分子生物钟机制的中心是一组时钟基因，在细胞水平上产生有节奏的振荡。在过去的几年中，来自不同领域的研究揭示了昼夜节律调节的复杂性和普遍性，揭示了时钟成分和涉及肿瘤发生的细胞途径之间的有趣联系。在这篇综述中，我们讨论了昼夜节律基因在血液学和激素相关恶性肿瘤中的新兴作用。这些新的见解表明，操纵昼夜节律生物学作为与癌症以及其他威胁生命的疾病作斗争的一种方式是可能的。

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《Cell cycle》 |2010年第6期|共7页
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Koeffler HP;
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正文语种 eng
中图分类细胞生物学;
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机译：去泛素化酶USP2对行为昼夜节律和时钟蛋白PER1的调控作用去泛素化酶USP2对行为昼夜节律和时钟蛋白PER1的调控作用
2. Sirtuins, melatonin and circadian rhythms: building a bridge between aging and cancer. [J] . Jung Hynes B, Reiter RJ, Ahmad N Journal of pineal research . 2010,第1期

机译：Sirtuins，褪黑激素和昼夜节律：在衰老和癌症之间架起一座桥梁。
3. Regulation of circadian rhythms and hypothalamic-pituitary-adrenal axis: an overlooked interaction in cancer. [J] . Innominato PF, Palesh O, Dhabhar FS, The lancet oncology . 2010,第9期

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4. Alzheimer Dementia Detection based on Circadian Rhythm Disorder of Heartrate [C] . Naoya Matsuda, Iko Nakari, Ryotaro Arai, Global Conference on Life Sciences and Technologies . 2021

机译：基于昼夜节律疾病的心率的阿尔茨海默痴呆症检测
5. Disruption of circadian rhythm impairs pancreatic islet function and increases susceptibility to beta-cell failure, while pathological complications of Type 2 Diabetes Mellitus have scant effects on the circadian system [D] . Qian, Jingyi 2015

机译：昼夜节律的破坏损害胰岛胰岛功能，并增加对β细胞衰竭的敏感性，而2型糖尿病的病理并发症对昼夜节律体系具有很少的影响
6. Research Priorities in the Area of Sleep/Circadian Rhythm and Aging Research: Commentary on Report and Research Agenda of the American Geriatrics Society and National Institute on Aging Bedside-to-Bench Conference on Sleep Circadian Rhythms and Aging: New Avenues for Improving Brain Health Physical Health and Functioning [O] . Constance H. Fung, Sigrid C. Veasey 2017

机译：睡眠/昼夜节律和衰老研究领域的研究重点：评述美国老年医学会和美国国立衰老床旁台会议报告研究议程昼夜节律和衰老会议：改进的新途径脑健康身体健康和机能
7. The Circadian Rhythm Gene Arntl2 Is a Metastasis Susceptibility Gene for Estrogen Receptor-Negative Breast Cancer. [O] . Ngoc-Han Ha, Jirong Long, Qiuyin Cai, 2016

机译：昼夜节律基因arntl2是雌激素受体 - 阴性乳腺癌的转移易感基因。

Circadian rhythms and cancer.

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