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首页> 外文期刊>Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology >Gliosarcoma: a clinical study.
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Gliosarcoma: a clinical study.

机译：胶质肉瘤：一项临床研究。

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BACKGROUND AND PURPOSE: Gliosarcomas are rare biphasic neoplasms of the central nervous system composed of a glioblastoma multiforme (GBM) admixed with a sarcomatous component. There are conflicting reports regarding their clinical aggressiveness. Four hundred and twenty-two consecutive patients with GBM were treated at our hospital between 1980 and 1999, among them 12 gliosarcomas. The goal of this study was to examine clinical features, treatment, survival and patterns of failure of gliosarcoma patients and to compare them with the entire group of GBM patients. This comparison was refined by a matched pair analysis with a group of 12 GBM patients selected for age, Karnofsky performance status, resection status, fractionation scheme and total dose (control GBM group). MATERIALS AND METHODS: Seven gliosarcoma patients were male, five female, with a median age of 56 years (range 37-76 years). The median tumor size was 4.5 cm (range 3-8 cm). The locations, all supratentorial, included temporal in six, parietal in five, frontal in four and occipital in one patient. All patients underwent tumor resection followed by postoperative radiation therapy. RESULTS: Median survival was 11.5 months for the gliosarcoma group, 8.1 months for the entire GBM group (log rank test, P=0.16) and 11.0 months for the control GBM group (log rank test, P=0.36). All gliosarcoma patients had local tumor recurrences and died due to neurologic causes within 19.3 months after radiation therapy. CONCLUSIONS: With regard to clinical features, survival and patterns of failure, gliosarcomas and GBM cannot be distinguished clinically. Therefore, the same principles should be applied for the treatment of these tumors.
机译：背景与目的：胶质肉瘤是中枢神经系统的罕见双相肿瘤，由多形性胶质母细胞瘤（GBM）与肉瘤成分混合而成。关于其临床攻击性的报道相互矛盾。 1980年至1999年间，我院共收治422例GBM病人，其中12例为神经胶质肉瘤。这项研究的目的是检查神经胶质肉瘤患者的临床特征，治疗，生存率和衰竭模式，并将其与整个GBM患者组进行比较。通过配对分析对一组12名GBM患者进行比较，该组患者的年龄，卡诺夫斯基机能状态，切除状态，分级方案和总剂量（对照组GBM组）选择。材料与方法：7例青光眼肉瘤患者为男性，5例女性，中位年龄为56岁（范围37-76岁）。中位肿瘤大小为4.5厘米（范围3-8厘米）。这些位置均为幕上位置，其中颞部6处，顶板5处，额叶4处，枕骨1例。所有患者均接受了肿瘤切除，随后进行了放射治疗。结果：神经胶质肉瘤组的中位生存期为11.5个月，整个GBM组为8.1个月（对数秩检验，P = 0.16），而对照组GBM组为11.0个月（对数秩检验，P = 0.36）。所有神经胶质肉瘤患者均在放疗后19.3个月内出现局部肿瘤复发并因神经系统原因死亡。结论：关于临床特征，存活率和失败模式，眼胶质肉瘤和GBM不能在临床上加以区分。因此，相同的原则应适用于这些肿瘤的治疗。

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