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首页> 外文期刊>Cell cycle >Evolutionary dynamics of two related malignant plasma cell lines.
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Evolutionary dynamics of two related malignant plasma cell lines.

机译：两种相关恶性浆细胞系的进化动力学。

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摘要

Cancer is the consequence of sequential acquisition of mutations within somatic cells. Mutations alter the relative reproductive fitness of cells, enabling the population to evolve in time as a consequence of selection. Cancer therapy itself can select for or against specific subclones. Given the large population of tumor cells, subclones inevitably emerge and their fate will depend on the evolutionary dynamics that define the interactions between such clones. Using a combination of in vitro studies and mathematical modeling, we describe the dynamic behavior of two cell lines isolated from the same patient at different time points of disease progression and show how the two clones relate to one another. We provide evidence that the two clones coexisted at the time of initial presentation. The dominant clone presented with biopsy proven cardiac AL amyloidosis. Initial therapy selected for the second clone that expanded leading to a change in the diagnosis to multiple myeloma. The evolutionary dynamics relating the two cell lines are discussed and a hypothesis is generated in regard to the mechanism of one of the phenotypic characteristics that is shared by these two cell lines.
机译：癌症是体细胞内相继获得突变的结果。突变改变了细胞的相对繁殖适应性，使种群由于选择而及时进化。癌症疗法本身可以选择支持或反对特定的亚克隆。考虑到大量肿瘤细胞，亚克隆不可避免地出现，它们的命运将取决于定义这些克隆之间相互作用的进化动力学。结合体外研究和数学建模，我们描述了从同一患者分离的两种细胞系在疾病进展的不同时间点的动态行为，并显示了这两个克隆之间的相互关系。我们提供的证据表明，两个克隆在首次展示时共存。活检显示的优势克隆证明了心脏AL淀粉样变性。为第二个克隆选择的初始疗法扩大了，导致对多发性骨髓瘤的诊断改变。讨论了与这两种细胞系有关的进化动力学，并就这两种细胞系共有的一种表型特征的机理产生了一个假设。

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