Competing events and costs of clinical trials: Analysis of a randomized trial in prostate cancer

Zakeri Kaveh; Rose Brent S.; DAmico Anthony V.; Jeong Jong-Hyeon; Mell Loren K.

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Competing events and costs of clinical trials: Analysis of a randomized trial in prostate cancer

机译：竞争事件和临床试验费用：前列腺癌随机试验的分析

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Background: Clinical trial costs may be reduced by identifying enriched subpopulations of patients with favorable risk profiles for the events of interest. However, increased selectivity affects accrual rates, with uncertain impact on clinical trial cost.

机译：背景：通过确定患者的丰富亚群可以降低感兴趣的事件的风险，可以降低临床试验成本。但是，选择性的提高会影响应计率，而对临床试验成本的影响不确定。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2015年第1期|共6页
作者
Zakeri Kaveh; Rose Brent S.; DAmico Anthony V.; Jeong Jong-Hyeon; Mell Loren K.;
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正文语种 eng
中图分类肿瘤学;
关键词
Costs; Clinical trials; Competing events;

机译：费用;临床试验;竞争事件;

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1. Competing events and costs of clinical trials: Analysis of a randomized trial in prostate cancer [J] . Zakeri Kaveh, Rose Brent S., DAmico Anthony V., Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2015,第1期

机译：竞争事件和临床试验费用：前列腺癌随机试验的分析
2. Re: Christopher JD Wallis, Refik Saskin, Richard Choo, et al. Surgery Versus Radiotherapy for Clinically-localized Prostate Cancer: A Systematic Review and Meta-analysis. Eur Urol 2016;70:21-30 Radical Prostatectomy Versus Radiation for Clinically Localized Prostate Cancer: Two Systematic Reviews and a Randomized Controlled Trial [J] . Lazar Ann A., Lizarraga Tania L. Ceron, Roach Mack III European urology . 2016,第1期

机译：回复：克里斯托弗·J·D·沃利斯（Christopher JD Wallis），萨克斯金（Refik Saskin），理查德·乔（Richard Choo）等。临床局限性前列腺癌的外科手术与放射治疗：系统评价和荟萃分析。 Eur Urol 2016; 70：21-30临床局部前列腺癌根治性前列腺切除术与放射治疗：两项系统评价和一项随机对照试验
3. Re: Liselotte MS Boeve, Maarten CCM Hulshof, Andre N. Vis, et al. Effect on Survival of Androgen Deprivation Therapy Alone Compared to Androgen Deprivation Therapy Combined with Concurrent Radiation Therapy to the Prostate in Patients with Primary Bone Metastatic Prostate Cancer in a Prospective Randomised Clinical Trial: Data from the HORRAD Trial. Eur Urol 2019; 75: 410-8 Future Steps for Definitive Therapy in Metastatic Prostate Cancer: Lessons from the HORRAD Trial [J] . Shinde Ashwin, Li Richard, Amini Arya, European urology . 2019,第3期

机译：Re：Liselotte Ms Boeve，Maarten CCM Hulshof，Andre N. Vis等人。与雄激素剥夺治疗相比，对雄激素剥夺治疗的生存对雄激素剥夺治疗与前瞻性随机临床试验中原发性骨转移前列腺癌前列腺患者的同时剥夺治疗的影响：来自血腥审判的数据。 EUR UROL 2019; 75：410-8转移性前列腺癌中的明确治疗的未来步骤：来自血轮试验的教训
4. Clinical Models for Testing Chemopreventative Agents in Prostate Cancer and Overview of SELECT: The Selenium and Vitamin E Cancer Prevention Trial [C] . Eric A. Klein International Society of Cancer Chemoprevention . 2003

机译：用于测试前列腺癌中化学预防剂的临床模型及选择：硒和维生素E癌预防试验
5. Effects of trial design on participation and costs in clinical trials, with an examination of cost analysis methods and data sources. [D] . Kilgore, Meredith L. 2004

机译：试验设计对临床试验参与和费用的影响，并检查费用分析方法和数据源。
6. A randomised controlled trial to determine the clinical and cost effectiveness of thulium laser transurethral vaporesection of the prostate (ThuVARP) versus transurethral resection of the prostate (TURP) in the National Health Service (NHS) – the UNBLOCS trial: a study protocol for a randomised controlled trial [O] . Jo Worthington, Hilary Taylor, Paul Abrams, 2017

机译：在国家卫生局（NHS）中确定前列腺th激光经尿道前列腺汽化术（ThuVARP）与经尿道前列腺电切术（TURP）的临床和成本效益的随机对照试验– UNBLOCS试验：一项随机研究方案对照试验
7. MP34-14 OVERALL ADVERSE EVENTS IN PATIENTS TREATED WITH ABIRATERONE AND ENZALUTAMIDE FOR METASTATIC CASTRATION RESISTANT PROSTATE CANCER: META-ANALYSIS OF RANDOMIZED CLINICAL TRIALS AND REAL-WORLD REPORTING PATTERNS FROM EUDRA VIGILANCE [O] . Cosimo De Nunzio*, Giorgia Tema, Riccardo Lombardo, 2019

机译：用AbiraTerone和烯醇酰胺用于转移阉割前列腺癌的患者的MP34-14患者的总体不良事件：eudra警惕的随机临床试验和现实世界报告模式的Meta分析

Competing events and costs of clinical trials: Analysis of a randomized trial in prostate cancer

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