Contrasting analytical and data-driven frameworks for radiogenomic modeling of normal tissue toxicities in prostate cancer

Coates James; Jeyaseelan Asha K.; Ybarra Norma; David Marc; Faria Sergio; Souhami Luis; Cury Fabio; Duclos Marie; El Naga Issam

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Contrasting analytical and data-driven frameworks for radiogenomic modeling of normal tissue toxicities in prostate cancer

机译：前列腺癌正常组织毒性的放射基因组学建模的对比分析和数据驱动框架

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Background and purpose: We explore analytical and data-driven approaches to investigate the integration of genetic variations (single nucleotide polymorphisms [SNPs] and copy number variations [CNVs]) with dosimetric and clinical variables in modeling radiation-induced rectal bleeding (RB) and erectile dysfunction (ED) in prostate cancer patients.

机译：背景与目的：我们探索分析和数据驱动的方法来研究遗传学变异（单核苷酸多态性[SNPs]和拷贝数变异[CNVs]）与剂量学和临床变量的整合，以模拟放射诱发的直肠出血（RB）和前列腺癌患者的勃起功能障碍（ED）。

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《Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology》 |2015年第1期|共7页
作者
Coates James; Jeyaseelan Asha K.; Ybarra Norma; David Marc; Faria Sergio; Souhami Luis; Cury Fabio; Duclos Marie; El Naga Issam;
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正文语种 eng
中图分类肿瘤学;
关键词
Radiogenomic modeling; Copy number variations; Normal tissue toxicity; Radiotherapy; Prostate cancer;

机译：放射基因组建模;拷贝数变异;正常组织毒性;放射治疗;前列腺癌;

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1. Contrasting analytical and data-driven frameworks for radiogenomic modeling of normal tissue toxicities in prostate cancer [J] . Coates James, Jeyaseelan Asha K., Ybarra Norma, Radiotherapy and oncology: Journal of the European Society for Therapeutic Radiology and Oncology . 2015,第1期

机译：前列腺癌正常组织毒性的放射基因组学建模的对比分析和数据驱动框架
2. Salvage reirradiation for local failure of prostate cancer after curative radiation therapy: Association of rectal toxicity with dose distribution and normal-tissue complication probability models [J] . Giovanna Dipasquale, Thomas Zilli, Claudio Fiorino, Advances in Radiation Oncology . 2018,第4期

机译：根治性放疗后的挽救性再照射对前列腺癌的局部衰竭：直肠毒性与剂量分布和正常组织并发症概率模型的关联
3. Multivariate normal tissue complication probability modeling of gastrointestinal toxicity after external beam radiotherapy for localized prostate cancer [J] . Laura Cella, Vittoria D’Avino, Raffaele Liuzzi, Radiation oncology . 2013,第1期

机译：局限性前列腺癌外照射后胃肠道毒性的多变量正常组织并发症概率模型
4. Evaluation and Visualization of Radiogenomic Modeling Frameworks for the Prediction of Normal Tissue Toxicities [C] . James Coates, Asha K Jeyaseelan, Norma Ybarra World Congress on Medical Physics and Biomedical Engineering . 2015

机译：辐射或可视化对正常组织毒性预测的辐射素质建模框架
5. Volume effects of late term normal tissue toxicity in prostate cancer radiotherapy. [D] . Bonta, Dacian Viorel. 2003

机译：前列腺癌放疗中晚期正常组织毒性的体积效应。
6. Salvage reirradiation for local failure of prostate cancer after curative radiation therapy: Association of rectal toxicity with dose distribution and normal-tissue complication probability models [O] . Giovanna Dipasquale, Thomas Zilli, Claudio Fiorino, 2018

机译：根治性放疗后的挽救性再照射对前列腺癌的局部衰竭：直肠毒性与剂量分布和正常组织并发症概率模型的关联
7. PO-0901: Evaluation of NTCP radiogenomic modelling frameworks in hypofractionated prostate cancer patients [O] . Coates J., Jeyaseelan A.K., Ybarra N., 2015

机译：PO-0901：评估超小规模前列腺癌患者的NTCP放射基因组建模框架

Contrasting analytical and data-driven frameworks for radiogenomic modeling of normal tissue toxicities in prostate cancer

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