A common feature of various age-dependent neurodegenerative disorders is the loss of specific types of neurons during disease progression. One promising yet daunting approach is to replenish the affected brain regions with newly generated healthy neurons. This prospect is made possible by the controlled differentiation of human embryonic stem cells (hESCs) and patient-specific induced pluripotent stem cells (iPSCs) into human neural progenitor cells (hNPCs). However, much needs to be learned about the molecular mechanisms that control the cellular behavior of hNPCs.
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