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Phosphorylation and the creation of interhomolog bias during meiosis in yeast.

机译:酵母减数分裂过程中的磷酸化作用和同源同源偏倚的产生。

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摘要

One of the fundamental differences between mitotic and meiotic cells is the source of homology used to repair double strand breaks (DSBs). Recombination in vegetative cells occurs preferentially between sister chromatids to repair unexpected DNA damage. In contrast, repair of programmed DSBs in meiotic cells occurs primarily between non-sister chromatids of homologous chromosomes. The resulting crossovers generate physical connections that promote accurate segregation at the first meiotic division. Mistakes in meiotic chromosome segregation in humans lead to infertility and birth defects. An important question, therefore, is how the bias for recombination between homologs is established during meiosis.
机译:有丝分裂和减数分裂细胞之间的根本区别之一是用于修复双链断裂(DSB)的同源性来源。营养细胞中的重组优先发生在姐妹染色单体之间,以修复意外的DNA损伤。相反,减数分裂细胞中程序化DSB的修复主要发生在同源染色体的非姐妹染色单体之间。所产生的交叉产生物理连接,从而促进在第一次减数分裂分裂时的精确分离。人类减数分裂染色体分离的错误会导致不育和先天缺陷。因此,一个重要的问题是在减数分裂过程中如何建立同源物之间重组的偏见。

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